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abca7 ATP-binding cassette, sub-family A (ABC1), member 7 [ Danio rerio (zebrafish) ]

Gene ID: 561460, updated on 2-Nov-2024

Summary

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Official Symbol
abca7provided by ZNC
Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-6
See related
AllianceGenome:ZFIN:ZDB-GENE-050517-6
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
abca1; zgc:172302
Summary
Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 9. Orthologous to human ABCA7 (ATP binding cassette subfamily A member 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See abca7 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (5584678..5659694)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (5638360..5713553)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch73-40i7.5 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene R3H domain containing 4 Neighboring gene AT-rich interactive domain 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. Hultqvist G, et al. PLoS One, 2012. PMID 22855693, Free PMC Article
  2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
  3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
  4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
  5. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC172302

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase ABCA1
Names
ATP-binding cassette 1, sub-family A, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    5584678..5659694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305796.3 → XP_009304071.2  phospholipid-transporting ATPase ABCA1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B3V5
    Conserved Domains (1) summary
    cl28181
    Location:1 → 2220
    AAA; ATPases associated with a variety of cellular activities

  2. XM_001920827.8 → XP_001920862.5  phospholipid-transporting ATPase ABCA1 isoform X2

    UniProtKB/TrEMBL
    A0A8M1QLA5
    Conserved Domains (1) summary
    cl28181
    Location:1 → 2212
    AAA; ATPases associated with a variety of cellular activities
Nucleotide Protein Strain
Heading Accession and Version

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