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cep126 centrosomal protein 126 [ Danio rerio (zebrafish) ]

Gene ID: 561486, updated on 27-Dec-2024

Summary

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Official Symbol
cep126provided by ZNC
Official Full Name
centrosomal protein 126provided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-24
See related
Ensembl:ENSDARG00000068398 AllianceGenome:ZFIN:ZDB-GENE-050419-24
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-3b8.4
Summary
Predicted to act upstream of or within cytoplasmic microtubule organization; mitotic spindle organization; and non-motile cilium assembly. Predicted to be located in centrosome and ciliary base. Is expressed in head. Orthologous to human CEP126 (centrosomal protein 126). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See cep126 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (37378315..37407779, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (37398865..37427359, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene Yes1 associated transcriptional regulator Neighboring gene uncharacterized LOC137488321 Neighboring gene uncharacterized LOC137488322 Neighboring gene uncharacterized LOC137488323

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish. Jia D, et al. Cell Death Dis, 2022 Nov 17. PMID 36396940, Free PMC Article
  2. yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets. Vázquez-Marín J, et al. Development, 2019 Jun 21. PMID 31142542
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein KIAA1377; centrosomal protein of 126 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    37378315..37407779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009293792.4 → XP_009292067.1  centrosomal protein of 126 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8M3AS44
    Conserved Domains (1) summary
    pfam15352
    Location:84 → 1034
    K1377; Susceptibility to monomelic amyotrophy

  2. XM_009293793.4 → XP_009292068.1  centrosomal protein of 126 kDa isoform X2

    UniProtKB/TrEMBL
    A0A8M3AJS2
    Related
    ENSDARP00000119630.1, ENSDART00000132315.3
    Conserved Domains (1) summary
    pfam15352
    Location:84 → 1033
    K1377; Susceptibility to monomelic amyotrophy

  3. XM_068214927.1 → XP_068071028.1  centrosomal protein of 126 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8M3AS44

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395040.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    123793..158924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473327.2 → XP_021329002.1  centrosomal protein of 126 kDa isoform X2

    UniProtKB/TrEMBL
    A0A8M9PD50
    Conserved Domains (1) summary
    pfam15352
    Location:84 → 1033
    K1377; Susceptibility to monomelic amyotrophy

  2. XM_021473326.2 → XP_021329001.1  centrosomal protein of 126 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q2W3
    Conserved Domains (1) summary
    pfam15352
    Location:84 → 1034
    K1377; Susceptibility to monomelic amyotrophy
Nucleotide Protein Strain
Heading Accession and Version

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