ptpn2b protein tyrosine phosphatase non-receptor type 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpn2bprovided by ZNC
Official Full Name: protein tyrosine phosphatase non-receptor type 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030909-8
See related: Ensembl:ENSDARG00000035986 AllianceGenome:ZFIN:ZDB-GENE-030909-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb806; ptpn2; PTP-1B; ptpn2l; zgc:55339; zgc:76973; wu:fc10h07
Summary: Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; anterior axial hypoblast; hatching gland; mesoderm; and vasculature. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (12362790..12392788, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (12443262..12473229, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fe01b05.y1 (e-PCR)
- UniSTS:195900

fc29f02.x1 (e-PCR)
- UniSTS:193457

fc10h07.x1 (e-PCR)
- UniSTS:192479

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 2

Names: protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 2, b; protein tyrosine phosphatase, non-receptor type 2, like

NP_997819.1

EC 3.1.3.48

XP_068071258.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212654.1 → NP_997819.1 tyrosine-protein phosphatase non-receptor type 2

See identical proteins and their annotated locations for NP_997819.1

Status: PROVISIONAL

Source sequence(s)

BC044373

UniProtKB/TrEMBL

B2GNN9, F6P5E9, Q803R3

Related

ENSDARP00000052238.4, ENSDART00000052239.6

Conserved Domains (2) summary

smart00194
Location:1 → 274

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:41 → 274

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...