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tysnd1 trypsin like peroxisomal matrix peptidase 1 [ Danio rerio (zebrafish) ]

Gene ID: 561667, updated on 4-Jan-2025

Summary

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Official Symbol
tysnd1provided by ZNC
Official Full Name
trypsin like peroxisomal matrix peptidase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8525
See related
Ensembl:ENSDARG00000074895 AllianceGenome:ZFIN:ZDB-GENE-030131-8525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb14b12
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing and regulation of fatty acid beta-oxidation. Predicted to act upstream of or within proteolysis. Predicted to be active in peroxisome. Orthologous to human TYSND1 (trypsin like peroxisomal matrix peptidase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See tysnd1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (30122107..30142094, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (30005396..30011637, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B12a Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene secretion associated, Ras related GTPase 1Ab Neighboring gene inorganic pyrophosphatase 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisomal leader peptide-processing protease
Names
trypsin domain containing 1
NP_001122182.1
XP_068068973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128710.1 → NP_001122182.1  peroxisomal leader peptide-processing protease

    See identical proteins and their annotated locations for NP_001122182.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162169
    UniProtKB/TrEMBL
    A0A8M9Q9R7, B3DFU6
    Related
    ENSDARP00000097678.1, ENSDART00000110157.3
    Conserved Domains (2) summary
    pfam13365
    Location:317 → 456
    Trypsin_2; Trypsin-like peptidase domain
    cl28339
    Location:145 → 242
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    30122107..30142094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212872.1 → XP_068068973.1  peroxisomal leader peptide-processing protease isoform X1

Nucleotide Protein
Heading Accession and Version

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