trim71 tripartite motif containing 71, E3 ubiquitin protein ligase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trim71provided by ZNC
Official Full Name: tripartite motif containing 71, E3 ubiquitin protein ligaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040128-1
See related: Ensembl:ENSDARG00000075593 AllianceGenome:ZFIN:ZDB-GENE-040128-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb205; lin41; fb93a12; sb:cb205; wu:fb93a12
Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within embryonic body morphogenesis. Is expressed in several structures, including nervous system; neural tube; pectoral fin musculature; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (7742660..7793457, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (7825314..7876111, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved.
Title: Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development.

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General gene information

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Markers

fb93a12.x1 (e-PCR)
- UniSTS:203528

fb97d06.x1 (e-PCR)
- UniSTS:191936

fi69b04.y1 (e-PCR)
- UniSTS:197863

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM71

Names: RING-type E3 ubiquitin transferase TRIM71; lin-41 homolog; protein lin-41 homolog; tripartite motif-containing 71; tripartite motif-containing protein 71

NP_001288260.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301331.1 → NP_001288260.1 E3 ubiquitin-protein ligase TRIM71

Status: VALIDATED

Source sequence(s)

BX511173, CABZ01061337

UniProtKB/TrEMBL

A0A8M1P6Z4

Related

ENSDARP00000101787.2, ENSDART00000113483.5

Conserved Domains (6) summary

smart00557
Location:429 → 526

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:554 → 804

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd14954
Location:529 → 813

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00630
Location:427 → 522

Filamin; Filamin/ABP280 repeat

pfam00643
Location:219 → 257

zf-B_box; B-box zinc finger

cl23765
Location:259 → 389

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits