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si:dkey-46g23.5 si:dkey-46g23.5 [ Danio rerio (zebrafish) ]

Gene ID: 562067, updated on 2-Nov-2024

Summary

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Official Symbol
si:dkey-46g23.5provided by ZNC
Official Full Name
si:dkey-46g23.5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9306
See related
Ensembl:ENSDARG00000008835 AllianceGenome:ZFIN:ZDB-GENE-030131-9306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa56g11; wu:fa56g11
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See si:dkey-46g23.5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (3432960..3448095, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (3650707..3665842, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:171446 Neighboring gene zgc:171445 Neighboring gene zgc:165453 Neighboring gene zgc:171426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC562067
Names
alpha-2-macroglobulin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201405.2 → NP_001188334.2  uncharacterized protein LOC562067 precursor

    Status: VALIDATED

    Source sequence(s)
    BC152015, BX322654, CABZ01040995, CD594314
    UniProtKB/TrEMBL
    A0A8M1NYK0, F1QS86
    Related
    ENSDARP00000073345.6, ENSDART00000078886.6
    Conserved Domains (6) summary
    cd02897
    Location:994 → 1269
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:776 → 864
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:170 → 261
    A2M_N; MG2 domain
    pfam07677
    Location:1388 → 1477
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1046 → 1269
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:506 → 650
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    3432960..3448095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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