tyw1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tyw1provided by ZNC
Official Full Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-688
See related: Ensembl:ENSDARG00000062987 AllianceGenome:ZFIN:ZDB-GENE-060929-688
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6898509; wu:fb74d01; zgc:153368
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; FMN binding activity; and tRNA-4-demethylwyosine synthase activity. Predicted to be involved in wybutosine biosynthetic process. Predicted to act upstream of or within tRNA processing. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to several human genes including TYW1 (tRNA-yW synthesizing protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (16739160..16872644, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (16803138..16936621, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc24c06.y1 (e-PCR)
- UniSTS:193190

fb74d01.x1 (e-PCR)
- UniSTS:191197

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA-4-demethylwyosine synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

Names: radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein

XP_017206468.1

EC 4.1.3.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077156.2 → NP_001070624.2 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

Status: VALIDATED

Source sequence(s)

BX649487

UniProtKB/Swiss-Prot

Q08C92

Related

ENSDARP00000117225.1, ENSDART00000142870.3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

16739160..16872644 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017350979.2 → XP_017206468.1 S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase isoform X1

UniProtKB/Swiss-Prot

Q08C92

UniProtKB/TrEMBL

A0A8M6Z1B5