lap3 leucine aminopeptidase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lap3provided by ZNC
Official Full Name: leucine aminopeptidase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060719-1
See related: Ensembl:ENSDARG00000061981 AllianceGenome:ZFIN:ZDB-GENE-060719-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7150907
Summary: Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; head; immature eye; midbrain; and musculature system. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (19418380..19431510, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (18725443..18738573, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data demonstrate that purpurin is a novel specific inhibitor of A-LAP and could be developed as a new anti-angiogenic agent.
Title: Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosol aminopeptidase

NP_001108319.1

EC 3.4.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114847.1 → NP_001108319.1 cytosol aminopeptidase

Status: PROVISIONAL

Source sequence(s)

BX901913

UniProtKB/TrEMBL

A0A8M1NGB5, A2BIC6

Related

ENSDARP00000083458.5, ENSDART00000089025.6

Conserved Domains (2) summary

PRK00913
Location:34 → 511

PRK00913; multifunctional aminopeptidase A; Provisional

cd00433
Location:32 → 510

Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...