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cast calpastatin [ Danio rerio (zebrafish) ]

Gene ID: 563084, updated on 14-Nov-2024

Summary

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Official Symbol
castprovided by ZNC
Official Full Name
calpastatinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050810-2
See related
Ensembl:ENSDARG00000058693 AllianceGenome:ZFIN:ZDB-GENE-050810-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb966; zgc:194249
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase inhibitor activity. Predicted to be involved in inhibition of cysteine-type endopeptidase activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cast in Genome Data Viewer
Location:
chromosome: 21
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11565888..11657036, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11473258..11564424, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100537030 Neighboring gene CD8a molecule Neighboring gene uncharacterized LOC137488783 Neighboring gene uncharacterized LOC108180799 Neighboring gene proprotein convertase subtilisin/kexin type 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization and expression of the calpastatin gene in Cyprinus carpio. Chen WX, et al. Genet Mol Res, 2015 Jul 3. PMID 26214419
  2. Characterization of calpastatin gene in fish: its potential role in muscle growth and fillet quality. Salem M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Aug. PMID 15990347
  3. Characterization and comparative expression of zebrafish calpain system genes during early development. Lepage SE, et al. Dev Dyn, 2008 Mar. PMID 18265014
  4. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Wang Y, et al. Genome Biol Evol, 2015 Oct 9. PMID 26454018, Free PMC Article
  5. Novel zebrafish caspase-3 substrates. Valencia CA, et al. Biochem Biophys Res Commun, 2007 Sep 21. PMID 17643392

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC194249

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calpastatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130591.2 → NP_001124063.2  calpastatin

    Status: VALIDATED

    Source sequence(s)
    BX005379, BX511081, BX927307
    UniProtKB/TrEMBL
    A0A8M1NI55
    Conserved Domains (1) summary
    pfam00748
    Location:421 → 568
    Calpain_inhib; Calpain inhibitor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    11565888..11657036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161041.5 → XP_005161098.1  calpastatin isoform X23

    UniProtKB/TrEMBL
    A0A8M2B7Y6
    Conserved Domains (1) summary
    pfam00748
    Location:326 → 473
    Calpain_inhib; Calpain inhibitor

  2. XM_005161036.5 → XP_005161093.1  calpastatin isoform X16

    UniProtKB/TrEMBL
    A0A8M2B7Y5
    Conserved Domains (1) summary
    pfam00748
    Location:394 → 541
    Calpain_inhib; Calpain inhibitor

  3. XM_005161025.5 → XP_005161082.1  calpastatin isoform X2

    UniProtKB/TrEMBL
    A0A8M2B865
    Conserved Domains (1) summary
    pfam00748
    Location:437 → 584
    Calpain_inhib; Calpain inhibitor

  4. XM_017352808.3 → XP_017208297.1  calpastatin isoform X36

    UniProtKB/TrEMBL
    A0A8M6YWX8
    Conserved Domains (1) summary
    pfam00748
    Location:288 → 435
    Calpain_inhib; Calpain inhibitor

  5. XM_005161049.5 → XP_005161106.1  calpastatin isoform X34

    See identical proteins and their annotated locations for XP_005161106.1

    UniProtKB/TrEMBL
    A0A8M2B7Z6
    Conserved Domains (1) summary
    pfam00748
    Location:292 → 439
    Calpain_inhib; Calpain inhibitor

  6. XM_005161043.5 → XP_005161100.1  calpastatin isoform X25

    See identical proteins and their annotated locations for XP_005161100.1

    UniProtKB/TrEMBL
    A0A8M2B873
    Conserved Domains (1) summary
    pfam00748
    Location:325 → 472
    Calpain_inhib; Calpain inhibitor

  7. XM_068215911.1 → XP_068072012.1  calpastatin isoform X17

    Related
    ENSDARP00000145456.1, ENSDART00000183811.1

  8. XM_005161034.5 → XP_005161091.1  calpastatin isoform X14

    See identical proteins and their annotated locations for XP_005161091.1

    UniProtKB/TrEMBL
    A0A0R4ILE0, A0A8M2B7Y0
    Conserved Domains (1) summary
    pfam00748
    Location:403 → 550
    Calpain_inhib; Calpain inhibitor

  9. XM_021468879.2 → XP_021324554.1  calpastatin isoform X28

    UniProtKB/TrEMBL
    A0A8M9PID2
    Conserved Domains (1) summary
    pfam00748
    Location:320 → 467
    Calpain_inhib; Calpain inhibitor

  10. XM_005161031.5 → XP_005161088.1  calpastatin isoform X10

    UniProtKB/TrEMBL
    A0A8M2B7Y7
    Conserved Domains (1) summary
    pfam00748
    Location:427 → 574
    Calpain_inhib; Calpain inhibitor

  11. XM_017352801.3 → XP_017208290.1  calpastatin isoform X6

    UniProtKB/TrEMBL
    A0A8M6YUH4

  12. XM_068215910.1 → XP_068072011.1  calpastatin isoform X9

    Related
    ENSDARP00000114134.1, ENSDART00000132699.3

  13. XM_005161027.5 → XP_005161084.1  calpastatin isoform X4

    UniProtKB/TrEMBL
    A0A8M2B7Y1, F1QZT8
    Related
    ENSDARP00000076055.4, ENSDART00000081614.4
    Conserved Domains (1) summary
    pfam00748
    Location:431 → 578
    Calpain_inhib; Calpain inhibitor

  14. XM_021468880.2 → XP_021324555.1  calpastatin isoform X30

    UniProtKB/TrEMBL
    A0A8M9PTZ9
    Conserved Domains (1) summary
    pfam00748
    Location:312 → 459
    Calpain_inhib; Calpain inhibitor

  15. XM_021468882.2 → XP_021324557.1  calpastatin isoform X35

    UniProtKB/TrEMBL
    A0A8M9P3E0
    Conserved Domains (1) summary
    pfam00748
    Location:289 → 436
    Calpain_inhib; Calpain inhibitor

  16. XM_005161046.5 → XP_005161103.1  calpastatin isoform X29

    UniProtKB/TrEMBL
    A0A8M2B800
    Conserved Domains (1) summary
    pfam00748
    Location:316 → 463
    Calpain_inhib; Calpain inhibitor

  17. XM_021468877.2 → XP_021324552.1  calpastatin isoform X26

    UniProtKB/TrEMBL
    A0A8M9P3D7
    Conserved Domains (1) summary
    pfam00748
    Location:322 → 469
    Calpain_inhib; Calpain inhibitor

  18. XM_005161040.5 → XP_005161097.1  calpastatin isoform X21

    UniProtKB/TrEMBL
    A0A8M2B7Z1
    Conserved Domains (1) summary
    pfam00748
    Location:349 → 496
    Calpain_inhib; Calpain inhibitor

  19. XM_005161037.5 → XP_005161094.1  calpastatin isoform X18

    UniProtKB/TrEMBL
    A0A8M2B7Z9
    Conserved Domains (1) summary
    pfam00748
    Location:384 → 531
    Calpain_inhib; Calpain inhibitor

  20. XM_017352802.3 → XP_017208291.1  calpastatin isoform X8

    UniProtKB/TrEMBL
    A0A8M6Z304

  21. XM_005161028.5 → XP_005161085.1  calpastatin isoform X5

    UniProtKB/TrEMBL
    A0A0R4IPE6, A0A8M2B7Z3
    Related
    ENSDARP00000136381.2, ENSDART00000162426.2
    Conserved Domains (1) summary
    pfam00748
    Location:427 → 574
    Calpain_inhib; Calpain inhibitor

  22. XM_068215912.1 → XP_068072013.1  calpastatin isoform X32

  23. XM_021468878.2 → XP_021324553.1  calpastatin isoform X27

    UniProtKB/TrEMBL
    A0A8M9PCR3
    Conserved Domains (1) summary
    pfam00748
    Location:322 → 469
    Calpain_inhib; Calpain inhibitor

  24. XM_021468881.2 → XP_021324556.1  calpastatin isoform X31

    UniProtKB/TrEMBL
    A0A8M9PQJ5
    Conserved Domains (1) summary
    pfam00748
    Location:299 → 446
    Calpain_inhib; Calpain inhibitor

  25. XM_021468876.2 → XP_021324551.1  calpastatin isoform X22

    UniProtKB/TrEMBL
    A0A8M9PQJ2
    Conserved Domains (1) summary
    pfam00748
    Location:326 → 473
    Calpain_inhib; Calpain inhibitor

  26. XM_021468875.2 → XP_021324550.1  calpastatin isoform X20

    UniProtKB/TrEMBL
    A0A8M9PTZ2
    Conserved Domains (1) summary
    pfam00748
    Location:355 → 502
    Calpain_inhib; Calpain inhibitor

  27. XM_021468874.2 → XP_021324549.1  calpastatin isoform X19

    UniProtKB/TrEMBL
    A0A8M9PIC9
    Conserved Domains (1) summary
    pfam00748
    Location:359 → 506
    Calpain_inhib; Calpain inhibitor

  28. XM_021468872.2 → XP_021324547.1  calpastatin isoform X15

    UniProtKB/TrEMBL
    A0A8M9P3D4
    Conserved Domains (1) summary
    pfam00748
    Location:394 → 541
    Calpain_inhib; Calpain inhibitor

  29. XM_021468871.2 → XP_021324546.1  calpastatin isoform X12

    UniProtKB/TrEMBL
    A0A8M9PQI9
    Conserved Domains (1) summary
    pfam00748
    Location:406 → 553
    Calpain_inhib; Calpain inhibitor

  30. XM_021468868.2 → XP_021324543.1  calpastatin isoform X3

    UniProtKB/TrEMBL
    A0A8M9PCQ8
    Conserved Domains (1) summary
    pfam00748
    Location:433 → 580
    Calpain_inhib; Calpain inhibitor

  31. XM_021468870.2 → XP_021324545.1  calpastatin isoform X11

    UniProtKB/TrEMBL
    A0A8M9PTY8
    Conserved Domains (1) summary
    pfam00748
    Location:410 → 557
    Calpain_inhib; Calpain inhibitor

  32. XM_021468869.2 → XP_021324544.1  calpastatin isoform X7

    UniProtKB/TrEMBL
    A0A8M9PIC6
    Conserved Domains (1) summary
    pfam00748
    Location:437 → 584
    Calpain_inhib; Calpain inhibitor

  33. XM_009295209.4 → XP_009293484.1  calpastatin isoform X1

    UniProtKB/TrEMBL
    A0A8M3ALB2
    Conserved Domains (1) summary
    pfam00748
    Location:437 → 584
    Calpain_inhib; Calpain inhibitor

  34. XM_005161048.5 → XP_005161105.1  calpastatin isoform X33

    See identical proteins and their annotated locations for XP_005161105.1

    UniProtKB/TrEMBL
    A0A8M2B7Z6
    Conserved Domains (1) summary
    pfam00748
    Location:292 → 439
    Calpain_inhib; Calpain inhibitor

  35. XM_005161042.5 → XP_005161099.1  calpastatin isoform X24

    See identical proteins and their annotated locations for XP_005161099.1

    UniProtKB/TrEMBL
    A0A8M2B873
    Conserved Domains (1) summary
    pfam00748
    Location:325 → 472
    Calpain_inhib; Calpain inhibitor

  36. XM_005161033.5 → XP_005161090.1  calpastatin isoform X13

    See identical proteins and their annotated locations for XP_005161090.1

    UniProtKB/TrEMBL
    A0A0R4ILE0, A0A8M2B7Y0
    Related
    ENSDARP00000135159.2, ENSDART00000171708.2
    Conserved Domains (1) summary
    pfam00748
    Location:403 → 550
    Calpain_inhib; Calpain inhibitor
Nucleotide Protein
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