aqp8a.2 aquaporin 8a, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aqp8a.2provided by ZNC
Official Full Name: aquaporin 8a, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1802
See related: Ensembl:ENSDARG00000071592 AllianceGenome:ZFIN:ZDB-GENE-070112-1802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158752
Summary: Enables urea transmembrane transporter activity and water transmembrane transporter activity. Acts upstream of or within digestive tract development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine and kidney. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (20355139..20362061, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (20233265..20240187, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

hbbe3 (e-PCR), detects polymorphism
- UniSTS:238255

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables urea transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aquaporin-8a.2

Names: aqp8ab; aquaporin-8ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080182.1 → NP_001073651.1 aquaporin-8a.2

See identical proteins and their annotated locations for NP_001073651.1

Status: PROVISIONAL

Source sequence(s)

BC129429

UniProtKB/TrEMBL

A1L2B1

Related

ENSDARP00000096730.3, ENSDART00000105952.4

Conserved Domains (1) summary

cl00200
Location:36 → 246

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...