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plpbp pyridoxal phosphate binding protein [ Danio rerio (zebrafish) ]

Gene ID: 563548, updated on 27-Dec-2024

Summary

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Official Symbol
plpbpprovided by ZNC
Official Full Name
pyridoxal phosphate binding proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1378
See related
Ensembl:ENSDARG00000060288 AllianceGenome:ZFIN:ZDB-GENE-030131-1378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prosc; fb69e01; wu:fb69e01; wu:fc14a09
Summary
Predicted to enable pyridoxal phosphate binding activity. Acts upstream of or within vitamin B6 metabolic process. Predicted to be active in cytoplasm. Used to study early-onset vitamin B6-dependent epilepsy 1. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See plpbp in Genome Data Viewer
Location:
chromosome: 23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (33963619..33976139)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (34037064..34049611)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:ch211-148l7.4 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene family with sequence similarity 50 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping. Kosuta C, et al. J Vis Exp, 2018 Jun 29. PMID 30010654, Free PMC Article
  2. PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights. Johnstone DL, et al. Brain, 2019 Mar 1. PMID 30668673, Free PMC Article
  3. Identification of p53-target genes in Danio rerio. Mandriani B, et al. Sci Rep, 2016 Sep 1. PMID 27581768, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vitamin B6 metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vitamin B6 metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pyridoxal phosphate homeostasis protein
Names
proline synthetase co-transcribed homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126409.2 → NP_001119881.1  pyridoxal phosphate homeostasis protein

    See identical proteins and their annotated locations for NP_001119881.1

    Status: VALIDATED

    Source sequence(s)
    CT025912
    UniProtKB/TrEMBL
    A0A8M2B9J5, B1H1M3
    Related
    ENSDARP00000116169.1, ENSDART00000140666.3
    Conserved Domains (1) summary
    cd06822
    Location:15 → 248
    PLPDE_III_YBL036c_euk; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    33963619..33976139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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