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plekhg6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [ Danio rerio (zebrafish) ]

Gene ID: 563725, updated on 9-Dec-2024

Summary

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Official Symbol
plekhg6provided by ZNC
Official Full Name
pleckstrin homology domain containing, family G (with RhoGef domain) member 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2517
See related
Ensembl:ENSDARG00000086056 AllianceGenome:ZFIN:ZDB-GENE-030131-2517
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc10d07; wu:fc10d07; si:ch211-215m13.2
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction and endothelial cell migration. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Orthologous to human PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See plekhg6 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17007089..17056561, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17099114..17148685, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-120k19.1 Neighboring gene ribosomal protein L18 Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene uncharacterized LOC137487920

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Cao M, et al. Dev Comp Immunol, 2022 Jul. PMID 35364135
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    17007089..17056561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292202.4 → XP_009290477.1  pleckstrin homology domain-containing family G member 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LH23, A0A8M3AQG8
    Related
    ENSDARP00000142553.1, ENSDART00000138715.3
    Conserved Domains (3) summary
    pfam00169
    Location:421 → 515
    PH; PH domain
    pfam00621
    Location:176 → 363
    RhoGEF; RhoGEF domain
    cl17171
    Location:418 → 514
    PH-like; Pleckstrin homology-like domain

  2. XM_009292201.4 → XP_009290476.1  pleckstrin homology domain-containing family G member 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ATA9
    Conserved Domains (3) summary
    pfam00169
    Location:421 → 515
    PH; PH domain
    pfam00621
    Location:176 → 363
    RhoGEF; RhoGEF domain
    cl17171
    Location:418 → 514
    PH-like; Pleckstrin homology-like domain

  3. XM_009292203.4 → XP_009290478.1  pleckstrin homology domain-containing family G member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AHZ2
    Conserved Domains (3) summary
    pfam00169
    Location:421 → 515
    PH; PH domain
    pfam00621
    Location:176 → 363
    RhoGEF; RhoGEF domain
    cl17171
    Location:418 → 514
    PH-like; Pleckstrin homology-like domain

  4. XM_068214108.1 → XP_068070209.1  pleckstrin homology domain-containing family G member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AHZ2
Nucleotide Protein Strain
Heading Accession and Version

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