U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kcnh2a potassium voltage-gated channel, subfamily H (eag-related), member 2a [ Danio rerio (zebrafish) ]

Gene ID: 563802, updated on 9-Dec-2024

Summary

Official Symbol
kcnh2aprovided by ZNC
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-699
See related
Ensembl:ENSDARG00000029881 AllianceGenome:ZFIN:ZDB-GENE-070912-699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kcnh2; kcnh2l; si:dkeyp-99c4.6
Summary
Predicted to enable inward rectifier potassium channel activity. Acts upstream of or within fin morphogenesis and negative regulation of calcineurin-mediated signaling. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; fin; gill; heart; and immune system. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See kcnh2a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24080590..24170737)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24425399..24512605)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene collagen, type XV, alpha 1b Neighboring gene solute carrier family 12 member 7a Neighboring gene uncharacterized LOC137487821 Neighboring gene microtubule associated protein 4 like Neighboring gene microRNA 736 Neighboring gene myosin heavy chain 7

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 2a
Names
potassium voltage-gated channel subfamily H member 2-like
potassium voltage-gated channel, subfamily H (eag-related), member 2 like
zerg-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042722.2NP_001036187.2  potassium voltage-gated channel subfamily H member 2a

    Status: VALIDATED

    Source sequence(s)
    BX000358, CR788285
    UniProtKB/TrEMBL
    A0A8M9QG33, Q108P2
    Related
    ENSDARP00000009558.7, ENSDART00000024058.10
    Conserved Domains (3) summary
    cd00038
    Location:744855
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:407670
    Ion_trans; Ion transport protein
    pfam13426
    Location:29130
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    24080590..24170737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)