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lrrc8db leucine rich repeat containing 8 VRAC subunit Db [ Danio rerio (zebrafish) ]

Gene ID: 563923, updated on 4-Jan-2025

Summary

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Official Symbol
lrrc8dbprovided by ZNC
Official Full Name
leucine rich repeat containing 8 VRAC subunit Dbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-487
See related
Ensembl:ENSDARG00000103840 AllianceGenome:ZFIN:ZDB-GENE-061013-487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lrrc8d; zgc:153223
Summary
Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in aspartate transmembrane transport; intracellular signal transduction; and monoatomic anion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See lrrc8db in Genome Data Viewer
Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (25171300..25181012, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (25070724..25081203, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene BarH-like homeobox 2 Neighboring gene zinc finger protein 326 Neighboring gene leucine rich repeat containing 8 VRAC subunit C Neighboring gene kynurenine aminotransferase 3, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos. Tseng YT, et al. Biol Open, 2020 Jan 29. PMID 31941702, Free PMC Article
  2. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153223

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables volume-sensitive anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine rich repeat containing 8 VRAC subunit Db
Names
leucine rich repeat containing 8 family, member D
leucine rich repeat containing 8 family, member Db

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077380.1 → NP_001070848.1  leucine rich repeat containing 8 VRAC subunit Db

    See identical proteins and their annotated locations for NP_001070848.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124653
    UniProtKB/TrEMBL
    A0A8M1NAA2, Q08BM6
    Related
    ENSDARP00000135454.1, ENSDART00000161585.2
    Conserved Domains (5) summary
    cd00116
    Location:544 → 821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:545 → 572
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 367
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam12799
    Location:689 → 729
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:641 → 701
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    25171300..25181012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168740.5 → XP_005168797.2  leucine rich repeat containing 8 VRAC subunit Db isoform X1

    See identical proteins and their annotated locations for XP_005168797.2

    UniProtKB/TrEMBL
    A0A8M1NAA2, Q08BM6
    Conserved Domains (5) summary
    cd00116
    Location:544 → 821
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:545 → 572
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 367
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam12799
    Location:689 → 729
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:641 → 701
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

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