uacab uveal autoantigen with coiled-coil domains and ankyrin repeats b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uacabprovided by ZNC
Official Full Name: uveal autoantigen with coiled-coil domains and ankyrin repeats bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030521-32
See related: Ensembl:ENSDARG00000060238 AllianceGenome:ZFIN:ZDB-GENE-030521-32
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj33f05; sb:cb472; wu:fj33f05
Summary: Predicted to be involved in intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; hindbrain neural plate; midbrain neural keel; musculature system; and nervous system. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (33800631..33868878, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (33529481..33597735, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fj33f05.x1 (e-PCR)
- UniSTS:199121

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uveal autoantigen with coiled-coil domains and ankyrin repeats b; uveal autoantigen with coiled-coil domains and ankyrin repeats protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

33800631..33868878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168952.5 → XP_005169009.1 uveal autoantigen with coiled-coil domains and ankyrin repeats protein isoform X1

UniProtKB/TrEMBL

A0A286Y884, A0A8M2BG92

Related

ENSDARP00000143336.1, ENSDART00000178746.2

Conserved Domains (7) summary

cl14654
Location:985 → 1265

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

cd12208
Location:1247 → 1339

septicolysin_like; putative septicolysin, cholesterol-dependent cytolysin family and related proteins

cd00204
Location:54 → 176

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR04523
Location:447 → 1212

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam12796
Location:61 → 153

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:27 → 77

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:56 → 87

ANK; ANK repeat [structural motif]
XM_021477874.2 → XP_021333549.1 uveal autoantigen with coiled-coil domains and ankyrin repeats protein isoform X2

UniProtKB/TrEMBL

A0A8M9Q8P3, F1QM39

Related

ENSDARP00000069215.4, ENSDART00000074729.6

Conserved Domains (5) summary

cd00204
Location:50 → 172

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:52 → 83

ANK; ANK repeat [structural motif]

pfam13637
Location:19 → 73

Ank_4; Ankyrin repeats (many copies)

cl25732
Location:413 → 1296

SMC_N; RecF/RecN/SMC N terminal domain

cl27539
Location:269 → 481

Peptidase_M23; Peptidase family M23