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si:dkey-269i1.4 si:dkey-269i1.4 [ Danio rerio (zebrafish) ]

Gene ID: 564835, updated on 9-Dec-2024

Summary

Official Symbol
si:dkey-269i1.4provided by ZNC
Official Full Name
si:dkey-269i1.4provided by ZNC
Primary source
ZFIN:ZDB-GENE-121214-37
See related
Ensembl:ENSDARG00000095744 AllianceGenome:ZFIN:ZDB-GENE-121214-37
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ctsl
Summary
Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See si:dkey-269i1.4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (16874625..16877136, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (16752757..16755251, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene wu:fb36g12 Neighboring gene uncharacterized LOC137496808 Neighboring gene zgc:174154 Neighboring gene si:dkey-26g8.4 Neighboring gene uncharacterized LOC108191771

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC174152

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uncharacterized protein LOC564835

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105680.2NP_001099150.2  uncharacterized protein LOC564835 precursor

    Status: VALIDATED

    Source sequence(s)
    BX322603
    UniProtKB/TrEMBL
    A8E587
    Related
    ENSDARP00000126582.1, ENSDART00000152593.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    16874625..16877136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)