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lrrc4.1 leucine rich repeat containing 4.1 [ Danio rerio (zebrafish) ]

Gene ID: 565021, updated on 4-Jan-2025

Summary

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Official Symbol
lrrc4.1provided by ZNC
Official Full Name
leucine rich repeat containing 4.1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-129
See related
Ensembl:ENSDARG00000069402 AllianceGenome:ZFIN:ZDB-GENE-041210-129
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lrrc4a; si:ch211-235l7.2
Summary
Predicted to be involved in modulation of chemical synaptic transmission and synapse organization. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in basal plate midbrain region; nervous system; and neural plate. Orthologous to human LRRC4 (leucine rich repeat containing 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See lrrc4.1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (19534820..19539086)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (19545373..19549637)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491540 Neighboring gene uncharacterized LOC137491541 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene uncharacterized LOC101883798 Neighboring gene paired box 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A cell surface interaction network of neural leucine-rich repeat receptors. Söllner C, et al. Genome Biol, 2009. PMID 19765300, Free PMC Article
  2. The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Panza P, et al. Neural Dev, 2015 Oct 22. PMID 26492970, Free PMC Article
  3. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
  4. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
  5. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in excitatory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic density protein 95 clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 4
Names
leucine rich repeat containing 4a
lrrc4b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    19534820..19539086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164787.5 → XP_005164844.1  leucine-rich repeat-containing protein 4

    UniProtKB/TrEMBL
    A0A8M2BBZ6, E9QDQ3, I7HJH4
    Related
    ENSDARP00000122550.1, ENSDART00000140028.2
    Conserved Domains (7) summary
    smart00013
    Location:43 → 77
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:361 → 443
    IG_like; Immunoglobulin like
    cd00116
    Location:93 → 323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 73
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05217
    Location:616 → 799
    STOP; STOP protein
    pfam13855
    Location:76 → 133
    LRR_8; Leucine rich repeat
    cl11960
    Location:372 → 443
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001030194.1: Suppressed sequence

    Description
    NM_001030194.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
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