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herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [ Danio rerio (zebrafish) ]

Gene ID: 565499, updated on 9-Dec-2024

Summary

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Official Symbol
herpud1provided by ZNC
Official Full Name
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-47
See related
Ensembl:ENSDARG00000024314 AllianceGenome:ZFIN:ZDB-GENE-050913-47
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:114134
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in telencephalon. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See herpud1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17600729..17608578)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17611573..17619512)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene microRNA 138 Neighboring gene solute carrier family 12 member 3 Neighboring gene cholesteryl ester transfer protein, plasma Neighboring gene NLR family, CARD domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Induction of endoplasmic reticulum stress markers in an acromegaly model. Elbialy A, et al. J Cell Biochem, 2022 Sep. PMID 35734917
  2. A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Ramdas Nair A, et al. Genomics, 2022 Jan. PMID 34863900
  3. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Pfeiffer J, et al. Dev Biol, 2018 Apr 15. PMID 29477339
  4. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Aanes H, et al. Genome Res, 2011 Aug. PMID 21555364, Free PMC Article
  5. Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Gu Q, et al. J Appl Toxicol, 2021 Feb. PMID 32691447

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC114134

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025537.1 → NP_001020708.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

    See identical proteins and their annotated locations for NP_001020708.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097190
    UniProtKB/TrEMBL
    Q4V8U9
    Related
    ENSDARP00000126535.1, ENSDART00000151934.3
    Conserved Domains (1) summary
    cl00155
    Location:12 → 92
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    17600729..17608578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159120.5 → XP_005159177.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A286YAA4, A0A8M2B617
    Related
    ENSDARP00000144135.1, ENSDART00000175258.2
    Conserved Domains (1) summary
    cl00155
    Location:12 → 92
    UBQ; Ubiquitin-like proteins

  2. XM_005159121.5 → XP_005159178.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5Q0
    Conserved Domains (1) summary
    cl00155
    Location:12 → 92
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version

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