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KLK10 kallikrein related peptidase 10 [ Homo sapiens (human) ]

Gene ID: 5655, updated on 2-Nov-2024

Summary

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Official Symbol
KLK10provided by HGNC
Official Full Name
kallikrein related peptidase 10provided by HGNC
Primary source
HGNC:HGNC:6358
See related
Ensembl:ENSG00000129451 MIM:602673; AllianceGenome:HGNC:6358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NES1; PRSSL1
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more
Orthologs
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Genomic context

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See KLK10 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51012739..51020097, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54101211..54108579, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51515995..51523353, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51509835-51510334 Neighboring gene kallikrein related peptidase 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51512731-51513231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51528951-51529509 Neighboring gene kallikrein related peptidase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51529510-51530067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51530627-51531183 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51533216-51533447 Neighboring gene kallikrein related peptidase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer. Huang W, et al. Cancer Lett, 2007 Jun 18. PMID 17182177
  2. Human kallikrein 10 in surgically removed human pituitary adenomas. Rotondo F, et al. Hormones (Athens), 2015 Apr-Jun. PMID 25553760
  3. Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study. Di Meo A, et al. Appl Immunohistochem Mol Morphol, 2015 Jul. PMID 25517869
  4. Overexpression of kallikrein gene 10 is a biomarker for predicting poor prognosis in gastric cancer. Jiao X, et al. World J Gastroenterol, 2013 Dec 28. PMID 24409072, Free PMC Article
  5. Clinical significance of kallikrein-related peptidase (KLK10) mRNA expression in colorectal cancer. Alexopoulou DK, et al. Clin Biochem, 2013 Oct. PMID 23499583

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.
    Title: MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.
  2. KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.
    Title: KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.
  3. KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
    Title: KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
  4. Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
    Title: Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
  5. Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
    Title: Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
  6. miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
    Title: miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
  7. MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
    Title: MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
  8. The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
    Title: The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
  9. Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
    Title: Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
  10. The data suggest that via inhibition of BCL-2 expression, overexpressed NES1 might enhance the effect of radiation therapy of (131)I uptake in hNIS overexpressed PC3 cells.
    Title: NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-10
Names
breast normal epithelial cell associated serine protease
kallikrein 10 protein 1
kallikrein 10 protein 12
kallikrein 10 protein 13
kallikrein 10 protein 2
kallikrein 10 protein 3
kallikrein 10 protein 4
kallikrein 10 protein 5
kallikrein 10 protein 7
kallikrein 10 protein 8
kallikrein 10 protein 9
normal epithelial cell-specific 1
protease serine-like 1
NP_001070968.1
NP_002767.2
NP_665895.1
XP_005259118.1
XP_005259119.1
XP_006723350.1
XP_006723352.1
XP_016882482.1
XP_047295058.1
XP_054177453.1
XP_054177454.1
XP_054177455.1
XP_054177456.1
XP_054177457.1
XP_054177458.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077500.2 → NP_001070968.1  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_001070968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AY561635, BM830577, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Related
    ENSP00000375681.1, ENST00000391805.5
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_002776.5 → NP_002767.2  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_002767.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AY561635, BC002710, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Related
    ENSP00000311746.2, ENST00000309958.7
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_145888.3 → NP_665895.1  kallikrein-10 preproprotein

    See identical proteins and their annotated locations for NP_665895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
    Source sequence(s)
    AC011473, AF024605, AY561635, BU685208
    Consensus CDS
    CCDS12817.1
    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Related
    ENSP00000351640.2, ENST00000358789.8
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51012739..51020097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439102.1 → XP_047295058.1  kallikrein-10 isoform X1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

  2. XM_006723289.4 → XP_006723352.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_006723352.1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_005259061.4 → XP_005259118.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_005259118.1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_006723287.5 → XP_006723350.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_006723350.1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_005259062.4 → XP_005259119.1  kallikrein-10 isoform X1

    See identical proteins and their annotated locations for XP_005259119.1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. XM_017026993.3 → XP_016882482.1  kallikrein-10 isoform X1

    UniProtKB/Swiss-Prot
    A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
    UniProtKB/TrEMBL
    W8GRM7, W8GWD1
    Conserved Domains (2) summary
    smart00020
    Location:49 → 269
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:49 → 272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54101211..54108579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321483.1 → XP_054177458.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6

  2. XM_054321482.1 → XP_054177457.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6

  3. XM_054321478.1 → XP_054177453.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6

  4. XM_054321479.1 → XP_054177454.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6

  5. XM_054321481.1 → XP_054177456.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6

  6. XM_054321480.1 → XP_054177455.1  kallikrein-10 isoform X1

    UniProtKB/TrEMBL
    Q6ICR6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43240.3 GenPept UniProtKB/Swiss-Prot:O43240

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