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eef1da eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) [ Danio rerio (zebrafish) ]

Gene ID: 565501, updated on 14-Nov-2024

Summary

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Official Symbol
eef1daprovided by ZNC
Official Full Name
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2740
See related
Ensembl:ENSDARG00000102291 AllianceGenome:ZFIN:ZDB-GENE-040426-2740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eef1d; zgc:66406
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See eef1da in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (50999704..51031260)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (51265476..51297040)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene finTRIM family, member 87 Neighboring gene finTRIM family, member 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55300, MGC111981

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
Names
elongation factor-1, delta, a
guanine nucleotide exchange protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177453.2 → NP_001170924.2  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)

    Status: VALIDATED

    Source sequence(s)
    EB797127, EG579283, EH475402
    UniProtKB/TrEMBL
    A0A0R4IA30, A0A8M1NUJ5
    Related
    ENSDARP00000130232.1, ENSDART00000158064.2
    Conserved Domains (2) summary
    cd00292
    Location:157 → 245
    EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
    pfam10587
    Location:125 → 150
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    50999704..51031260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358747.3 → XP_017214236.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1P2

  2. XM_021480943.2 → XP_021336618.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X2

    UniProtKB/TrEMBL
    A0A8M9QAS6
    Conserved Domains (2) summary
    pfam00736
    Location:358 → 441
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:321 → 346
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  3. XM_021480949.2 → XP_021336624.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X4

    UniProtKB/TrEMBL
    A0A8M9QG85
    Conserved Domains (2) summary
    pfam00736
    Location:334 → 417
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:297 → 322
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  4. XM_068224637.1 → XP_068080738.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X3

  5. XM_005163594.4 → XP_005163651.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X5

    UniProtKB/TrEMBL
    A0A8M2BAS2
    Related
    ENSDARP00000134060.1, ENSDART00000165746.2
    Conserved Domains (2) summary
    cd00292
    Location:203 → 291
    EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
    pfam10587
    Location:171 → 196
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

  6. XM_005163595.4 → XP_005163652.1  eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein) isoform X6

    UniProtKB/TrEMBL
    A0A8M2BAX4
    Related
    ENSDARP00000139875.1, ENSDART00000164775.2
    Conserved Domains (3) summary
    cd00292
    Location:181 → 269
    EF1B; Elongation factor 1 beta (EF1B) guanine nucleotide exchange domain. EF1B catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP, an important step in the elongation cycle of the protein biosynthesis. EF1A binds to and delivers the aminoacyl ...
    pfam10587
    Location:149 → 174
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
    cl01287
    Location:91 → 205
    AE_Prim_S_like; AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis ...
Nucleotide Protein Strain
Heading Accession and Version

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