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asap1b ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b [ Danio rerio (zebrafish) ]

Gene ID: 565859, updated on 14-Nov-2024

Summary

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Official Symbol
asap1bprovided by ZNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091112-16
See related
Ensembl:ENSDARG00000039729 AllianceGenome:ZFIN:ZDB-GENE-091112-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
asap2; si:dkey-37o8.2
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within defense response to bacterium and positive regulation of macrophage migration. Predicted to be located in cytoplasm. Is expressed in head. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See asap1b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (10901418..11051245, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (10761058..10909589, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 49 member Bb Neighboring gene eukaryotic translation elongation factor 1 alpha 1, like 3 Neighboring gene microRNA mir-7147 Neighboring gene GTPase IMAP family member 4 Neighboring gene charged multivesicular body protein 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Cui J, et al. Front Cell Infect Microbiol, 2020. PMID 33194781, Free PMC Article
  2. The Role of ARF6 in Biliary Atresia. Ningappa M, et al. PLoS One, 2015. PMID 26379158, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.
    Title: Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Names
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
asap1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    10901418..11051245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003201277.6 → XP_003201325.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A2R8PVI8, A0A2R8RMX4, A0A8M1RTJ8
    Related
    ENSDARP00000144883.1, ENSDART00000186494.1
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1024 → 1080
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:561 → 690
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316 → 422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:600 → 634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439 → 555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:788 → 1012
    Atrophin-1; Atrophin-1 family

  2. XM_009297312.4 → XP_009295587.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ANG5, E7FGT3
    Related
    ENSDARP00000120174.1, ENSDART00000145466.3
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1075 → 1131
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:561 → 690
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316 → 422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:600 → 634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439 → 555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:789 → 1063
    Atrophin-1; Atrophin-1 family

  3. XM_021470289.2 → XP_021325964.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PM69, E7FGT3
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1076 → 1132
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:562 → 691
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:317 → 423
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601 → 635
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:440 → 556
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:790 → 1064
    Atrophin-1; Atrophin-1 family

  4. XM_068217167.1 → XP_068073268.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

  5. XM_068217169.1 → XP_068073270.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

  6. XM_009297310.4 → XP_009295585.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AVY1, E7FGT3
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1078 → 1134
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:564 → 693
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:603 → 637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442 → 558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:792 → 1066
    Atrophin-1; Atrophin-1 family

  7. XM_068217168.1 → XP_068073269.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    Related
    ENSDARP00000148169.1, ENSDART00000191320.1
Nucleotide Protein Strain
Heading Accession and Version

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