ca9 carbonic anhydrase IX [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ca9provided by ZNC
Official Full Name: carbonic anhydrase IXprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080818-5
See related: Ensembl:ENSDARG00000102300 AllianceGenome:ZFIN:ZDB-GENE-080818-5
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb77; sb:cb77
Summary: Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in brain; digestive system; eye; muscle; and renal system. Human ortholog(s) of this gene implicated in hepatitis B and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (6415576..6454452, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (6414369..6453213, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fe47g07.x1 (e-PCR)
- UniSTS:196494

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carbonic anhydrase 9; carbonic anhydrase 14

XP_009303384.1

EC 4.2.1.1

XP_694982.3

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

6415576..6454452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_689890.8 → XP_694982.3 carbonic anhydrase 14 isoform X2

UniProtKB/TrEMBL

A0A8N7TDP2

Related

ENSDARP00000134317.1, ENSDART00000168549.2

Conserved Domains (1) summary

cd03150
Location:48 → 294

alpha_CA_IX; Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed ...
XM_009305109.3 → XP_009303384.1 carbonic anhydrase 14 isoform X1

UniProtKB/TrEMBL

A0A8M3B325

Conserved Domains (1) summary

cd03150
Location:48 → 294

alpha_CA_IX; Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed ...