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znf423 zinc finger protein 423 [ Danio rerio (zebrafish) ]

Gene ID: 566696, updated on 2-Nov-2024

Summary

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Official Symbol
znf423provided by ZNC
Official Full Name
zinc finger protein 423provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4368
See related
Ensembl:ENSDARG00000059707 AllianceGenome:ZFIN:ZDB-GENE-030131-4368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc95d03; zgc:158272; si:ch211-212o1.3; si:ch211-216l23.1
Summary
Predicted to enable chromatin insulator sequence binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in nucleus. Predicted to be active in chromosome. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See znf423 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17786028..17995064)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17796904..18005998)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:ch211-216l23.2 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene uncharacterized LOC101885646 Neighboring gene si:ch211-212o1.2 Neighboring gene cerebellin 1 precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression. Ariza-Cosano A, et al. BMC Genomics, 2012 Dec 19. PMID 23253453, Free PMC Article
  2. MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. Tsai YW, et al. Cells, 2021 Dec 6. PMID 34943942, Free PMC Article
  3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158272

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 423
Names
zinc finger protein 423-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080030.1 → NP_001073499.1  zinc finger protein 423

    See identical proteins and their annotated locations for NP_001073499.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129184
    UniProtKB/Swiss-Prot
    A1L1R6, Q1L943, Q1LX66
    Related
    ENSDARP00000146416.1, ENSDART00000189493.1
    Conserved Domains (2) summary
    COG5048
    Location:151 → 256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:152 → 172
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    17786028..17995064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159129.5 → XP_005159186.1  zinc finger protein 423 isoform X1

    UniProtKB/TrEMBL
    A0A2U3TVM2, A0A8M2B5L6
    Related
    ENSDARP00000077731.4, ENSDART00000083296.6
    Conserved Domains (2) summary
    COG5048
    Location:151 → 256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:152 → 172
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_005159130.5 → XP_005159187.1  zinc finger protein 423 isoform X2

    UniProtKB/TrEMBL
    A0A2R8PYF9, A0A8M2B639
    Related
    ENSDARP00000144947.1, ENSDART00000187095.1
    Conserved Domains (2) summary
    COG5048
    Location:131 → 236
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_068214810.1 → XP_068070911.1  zinc finger protein 423 isoform X3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395019.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    85247..300664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L1R6.1 GenPept UniProtKB/Swiss-Prot:A1L1R6

Gene LinkOut

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