flt3 fms related receptor tyrosine kinase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flt3provided by ZNC
Official Full Name: fms related receptor tyrosine kinase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050114-4
See related: Ensembl:ENSDARG00000058503 AllianceGenome:ZFIN:ZDB-GENE-050114-4
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-140b10.8
Summary: Predicted to enable growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within macrophage differentiation and myeloid cell development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including ball; digestive system; hematopoietic system; kidney; and pericardial region. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21691966..21713961, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21547194..21568767, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first report to demonstrate that FLT3-ITD zebrafish had a malignant myeloid phenotype and that NPM1-Mut could enhance the disease progression
Title: Overexpression of FLT3-ITD driven by spi-1 results in expanded myelopoiesis with leukemic phenotype in zebrafish.
This study provides novel insight into the role of flt3 during hematopoiesis and establishes a zebrafish model of FLT3-ITD(+) and FLT3-TKD(+) acute myeloid leukemia that may facilitate high-throughput screening of novel and personalized agents.
Title: Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myeloid cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: receptor-type tyrosine-protein kinase FLT3

Names: fms-related tyrosine kinase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

21691966..21713961 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470319.1 → XP_021325994.1 receptor-type tyrosine-protein kinase FLT3

UniProtKB/TrEMBL

A0A8M9PM96, E7F1P1

Related

ENSDARP00000075800.3, ENSDART00000081357.4

Conserved Domains (2) summary

smart00408
Location:225 → 283

IGc2; Immunoglobulin C-2 Type

cl21453
Location:522 → 907

PKc_like; Protein Kinases, catalytic domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395171.1 Reference GRCz11 ALT_DRER_TU_1

Range

361015..382683 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001921725.5 → XP_001921760.3 receptor-type tyrosine-protein kinase FLT3

UniProtKB/TrEMBL

A0A8M1QKN2

Conserved Domains (2) summary

smart00408
Location:225 → 283

IGc2; Immunoglobulin C-2 Type

cl21453
Location:522 → 907

PKc_like; Protein Kinases, catalytic domain