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dub duboraya [ Danio rerio (zebrafish) ]

Gene ID: 566846, updated on 4-Jan-2025

Summary

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Official Symbol
dubprovided by ZNC
Official Full Name
duborayaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-81
See related
Ensembl:ENSDARG00000059774 AllianceGenome:ZFIN:ZDB-GENE-060825-81
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153303
Summary
Acts upstream of or within cilium assembly and heart development. Is expressed in blood island; cardiovascular system; pronephric duct; somite; and tail bud. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See dub in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22917981..22951627, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22881376..22915021, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene guanylate cyclase activator 1d Neighboring gene cysteinyl leukotriene receptor 2a Neighboring gene retinoblastoma 1 Neighboring gene uncharacterized LOC137488813

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Oishi I, et al. Nat Genet, 2006 Nov. PMID 17013396
  2. Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration. Kapuria S, et al. Development, 2022 Feb 15. PMID 35088848, Free PMC Article
  3. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Yee NS, et al. Dis Model Mech, 2011 Mar. PMID 21183474, Free PMC Article
  4. From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development. Khodiyar VK, et al. F1000Res, 2013. PMID 24627794, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of a zebrafish gene, termed duboraya (dub), that is essential for ciliogenesis and left-right patterning.
    Title: Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC153303, MGC191431

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart jogging IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macrophage apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within non-canonical Wnt signaling pathway involved in heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
duboraya

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045422.1 → NP_001038887.1  duboraya

    See identical proteins and their annotated locations for NP_001038887.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122224
    UniProtKB/TrEMBL
    Q0P484
    Related
    ENSDARP00000151739.1, ENSDART00000180129.1
    Conserved Domains (1) summary
    pfam15255
    Location:71 → 178
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    22917981..22951627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161193.5 → XP_005161250.1  duboraya isoform X1

    UniProtKB/TrEMBL
    A0A8M2B856
    Conserved Domains (1) summary
    pfam15255
    Location:42 → 149
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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