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myo18aa myosin XVIIIAa [ Danio rerio (zebrafish) ]

Gene ID: 566880, updated on 27-Dec-2024

Summary

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Official Symbol
myo18aaprovided by ZNC
Official Full Name
myosin XVIIIAaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080425-5
See related
Ensembl:ENSDARG00000075752 AllianceGenome:ZFIN:ZDB-GENE-080425-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
myo18l2
Summary
Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Acts upstream of or within Golgi organization; cell-matrix adhesion; and striated muscle cell development. Predicted to be part of myosin complex. Is expressed in somite border. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See myo18aa in Genome Data Viewer
Location:
chromosome: 10
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36950774..37075320, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (37006267..37131623, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 12a Neighboring gene seizure related 6 homolog a Neighboring gene vascular endothelial zinc finger 1a Neighboring gene CUE domain containing 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myo18b is essential for sarcomere assembly in fast skeletal muscle. Berger J, et al. Hum Mol Genet, 2017 Mar 15. PMID 28104788
  2. The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish. Cao J, et al. J Genet Genomics, 2014 Aug 20. PMID 25160974
  3. Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Cao JM, et al. Sci Rep, 2016 Nov 8. PMID 27824130, Free PMC Article
  4. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Full loss of myo18b function results in a complete lack of sarcomeric structure, revealing a highly surprising and essential role for myo18b in sarcomere assembly. Importantly, scattered thin and thick filaments assemble throughout the sarcoplasm. These observations suggest a novel model of sarcomere assembly where Myo18b coordinates the integration of preformed thick and thin filaments into the sarcomere
    Title: Myo18b is essential for sarcomere assembly in fast skeletal muscle.
  2. MYO18A likely functions in the adhesion process that maintains the stable attachment of myofibers to ECM (extracellular matrix) and muscle integrity during early development
    Title: The PDZ-containing unconventional myosin XVIIIA regulates embryonic muscle integrity in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin XVIIIAa; unconventional myosin-XVIIIa
Names
myo18b
myosin XVIII-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    36950774..37075320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223999.1 → XP_068080100.1  unconventional myosin-XVIIIa isoform X6

    UniProtKB/TrEMBL
    A0A0R4J7R2, A0A8N7T868
    Related
    ENSDARP00000118849.2, ENSDART00000132023.3

  2. XM_068223998.1 → XP_068080099.1  unconventional myosin-XVIIIa isoform X5

    UniProtKB/TrEMBL
    A0A0R4J7R2, A0A8N7T868

  3. XM_068223994.1 → XP_068080095.1  unconventional myosin-XVIIIa isoform X1

    UniProtKB/TrEMBL
    A0A8M3AX53, A0A8M9QL86

  4. XM_068223997.1 → XP_068080098.1  unconventional myosin-XVIIIa isoform X4

    UniProtKB/TrEMBL
    A0A8M9PUB6

  5. XM_068223996.1 → XP_068080097.1  unconventional myosin-XVIIIa isoform X3

    UniProtKB/TrEMBL
    A0A8M9QH80

  6. XM_068224002.1 → XP_068080103.1  unconventional myosin-XVIIIa isoform X9

    UniProtKB/TrEMBL
    A0A8M9QCN6

  7. XM_068223995.1 → XP_068080096.1  unconventional myosin-XVIIIa isoform X2

    UniProtKB/TrEMBL
    A0A8M3BDA6

  8. XM_068224001.1 → XP_068080102.1  unconventional myosin-XVIIIa isoform X8

    UniProtKB/TrEMBL
    A0A8M3AX31

  9. XM_068223993.1 → XP_068080094.1  unconventional myosin-XVIIIa isoform X1

    UniProtKB/TrEMBL
    A0A8M3AX53, A0A8M9QL86

  10. XM_068224000.1 → XP_068080101.1  unconventional myosin-XVIIIa isoform X7

    UniProtKB/TrEMBL
    A0A8M9Q6N9
Nucleotide Protein Strain
Heading Accession and Version

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