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stag2a STAG2 cohesin complex component a [ Danio rerio (zebrafish) ]

Gene ID: 567168, updated on 9-Dec-2024

Summary

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Official Symbol
stag2aprovided by ZNC
Official Full Name
STAG2 cohesin complex component aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3432
See related
Ensembl:ENSDARG00000011783 AllianceGenome:ZFIN:ZDB-GENE-030131-3432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc39a01; wu:fc39a01; si:dkeyp-20g2.6
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromatin. Predicted to be part of cohesin complex. Predicted to be active in nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See stag2a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23488055..23517803, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22984255..23014010, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, AMPA 3a Neighboring gene si:dkeyp-20g2.1 Neighboring gene acyl-CoA synthetase long chain family member 4b Neighboring gene CWC15 spliceosome associated protein homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Ketharnathan S, et al. Front Cell Dev Biol, 2020. PMID 33365313, Free PMC Article
  2. Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Avagyan S, et al. Science, 2021 Nov 5. PMID 34735227
  3. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
  4. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
  5. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cohesin subunit SA-2a
Names
stromal antigen 2
stromal antigen 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100028.1 → NP_001093498.1  cohesin subunit SA-2a

    Status: PROVISIONAL

    Source sequence(s)
    CR926467
    UniProtKB/TrEMBL
    A0A8M1NE13, A5WV17
    Related
    ENSDARP00000112624.1, ENSDART00000137655.2
    Conserved Domains (1) summary
    pfam08514
    Location:144 → 252
    STAG; STAG domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    23488055..23517803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301356.4 → XP_009299631.1  cohesin subunit SA-2a isoform X2

    UniProtKB/TrEMBL
    A0A8M3B9I6
    Conserved Domains (1) summary
    pfam08514
    Location:143 → 251
    STAG; STAG domain

  2. XM_017356146.3 → XP_017211635.1  cohesin subunit SA-2a isoform X1

    UniProtKB/TrEMBL
    A0A8M1NE13, A5WV17
    Conserved Domains (1) summary
    pfam08514
    Location:144 → 252
    STAG; STAG domain
Nucleotide Protein Strain
Heading Accession and Version

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