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Nfu1 NFU1 iron-sulfur cluster scaffold [ Mus musculus (house mouse) ]

Gene ID: 56748, updated on 9-Aug-2024

Summary

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Official Symbol
Nfu1provided by MGI
Official Full Name
NFU1 iron-sulfur cluster scaffoldprovided by MGI
Primary source
MGI:MGI:1913290
See related
Ensembl:ENSMUSG00000029993 AllianceGenome:MGI:1913290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI-33; Hirip5; 0610006G17Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; genitourinary system; liver; and spleen. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 20.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nfu1 in Genome Data Viewer
Location:
6 D1; 6 37.76 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86986040..87005443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87009234..87028461)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene STARR-positive B cell enhancer ABC_E6452 Neighboring gene STARR-seq mESC enhancer starr_16547 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:87025148-87025378 Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene predicted gene, 52909

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of human and mouse HIRA-interacting protein-5 (HIRIP5), two mammalian representatives in a family of phylogenetically conserved proteins with a role in the biogenesis of Fe/S proteins. Lorain S, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342215
  2. The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain. Ganesh S, et al. Hum Mol Genet, 2003 Sep 15. PMID 12915448
  3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Names
HIRA-interacting protein 5
histone cell cycle regulation defective interacting protein 5
mHIRIP5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170591.1 → NP_001164062.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001164062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145558, CD775268
    Consensus CDS
    CCDS51836.1
    UniProtKB/TrEMBL
    A0A0N4SUH8
    Related
    ENSMUSP00000032060.9, ENSMUST00000032060.15
    Conserved Domains (2) summary
    pfam01106
    Location:174 → 240
    NifU; NifU-like domain
    pfam08712
    Location:59 → 146
    Nfu_N; Scaffold protein Nfu/NifU N terminal

  2. NM_020045.3 → NP_064429.2  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_064429.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK003730, AK145558, CD775268
    Consensus CDS
    CCDS85088.1
    UniProtKB/Swiss-Prot
    Q3ULE0, Q6VNZ7, Q8CF80, Q9D1B7, Q9QZ23
    Related
    ENSMUSP00000113332.3, ENSMUST00000117583.8
    Conserved Domains (2) summary
    pfam01106
    Location:173 → 239
    NifU; NifU-like domain
    pfam08712
    Location:59 → 146
    Nfu_N; Scaffold protein Nfu/NifU N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86986040..87005443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152244.1 → XP_036008137.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1

    Conserved Domains (2) summary
    smart00932
    Location:59 → 219
    Nfu_N; Scaffold protein Nfu/NifU N terminal
    pfam01106
    Location:247 → 313
    NifU; NifU-like domain

  2. XM_036152245.1 → XP_036008138.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X2

    Conserved Domains (2) summary
    smart00932
    Location:59 → 219
    Nfu_N; Scaffold protein Nfu/NifU N terminal
    pfam01106
    Location:246 → 312
    NifU; NifU-like domain

  3. XM_006506419.2 → XP_006506482.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_006506482.1

    UniProtKB/TrEMBL
    A0A0N4SUH8
    Related
    ENSMUSP00000113637.3, ENSMUST00000120240.8
    Conserved Domains (2) summary
    pfam01106
    Location:174 → 240
    NifU; NifU-like domain
    pfam08712
    Location:59 → 146
    Nfu_N; Scaffold protein Nfu/NifU N terminal

  4. XM_006506420.3 → XP_006506483.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_006506483.1

    UniProtKB/Swiss-Prot
    Q3ULE0, Q6VNZ7, Q8CF80, Q9D1B7, Q9QZ23
    Conserved Domains (2) summary
    pfam01106
    Location:173 → 239
    NifU; NifU-like domain
    pfam08712
    Location:59 → 146
    Nfu_N; Scaffold protein Nfu/NifU N terminal

  5. XM_036152246.1 → XP_036008139.1  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X5

    Conserved Domains (2) summary
    smart00932
    Location:34 → 81
    Nfu_N; Scaffold protein Nfu/NifU N terminal
    pfam01106
    Location:109 → 175
    NifU; NifU-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ23.2 GenPept UniProtKB/Swiss-Prot:Q9QZ23

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