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ctnna2 catenin (cadherin-associated protein), alpha 2 [ Danio rerio (zebrafish) ]

Gene ID: 567500, updated on 4-Jan-2025

Summary

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Official Symbol
ctnna2provided by ZNC
Official Full Name
catenin (cadherin-associated protein), alpha 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060815-3
See related
Ensembl:ENSDARG00000024785 AllianceGenome:ZFIN:ZDB-GENE-060815-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
catna2l; bZ1H10.1; im:5410539; si:rp71-1h10.1
Summary
Predicted to enable actin filament binding activity and beta-catenin binding activity. Predicted to be involved in several processes, including brain morphogenesis; neuron projection morphogenesis; and regulation of synapse structural plasticity. Predicted to act upstream of or within cell adhesion and cell differentiation. Predicted to be located in axon and cytoplasm. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in female organism. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ctnna2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (42225130..43035729)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (41523882..42334573)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495652 Neighboring gene uncharacterized LOC137495655 Neighboring gene adrenoceptor alpha 1D Neighboring gene uncharacterized LOC101882853 Neighboring gene leucine rich repeat transmembrane neuronal 1 Neighboring gene succinate-CoA ligase GDP/ADP-forming subunit alph Neighboring gene CDGSH iron sulfur domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Rödel CJ, et al. Circ Res, 2019 Oct 25. PMID 31495257
  2. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article
  3. Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. Merkes C, et al. PLoS One, 2015. PMID 25617839, Free PMC Article
  4. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
  5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brain morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synapse structural plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
catenin alpha-2
Names
alpha N-catenin
catenin, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159372.1 → NP_001152844.1  catenin alpha-2

    See identical proteins and their annotated locations for NP_001152844.1

    Status: PROVISIONAL

    Source sequence(s)
    AL626804, BX927206, CR925858, CT997814, CT998561, CU076051
    UniProtKB/Swiss-Prot
    B7ZC77
    Related
    ENSDARP00000092080.4, ENSDART00000101306.6
    Conserved Domains (1) summary
    pfam01044
    Location:82 → 826
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    42225130..43035729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160072.5 → XP_005160129.1  catenin alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B6X9
    Conserved Domains (1) summary
    pfam01044
    Location:82 → 866
    Vinculin; Vinculin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7ZC77.1 GenPept UniProtKB/Swiss-Prot:B7ZC77

Gene LinkOut

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