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Clec1b C-type lectin domain family 1, member b [ Mus musculus (house mouse) ]

Gene ID: 56760, updated on 12-May-2024

Summary

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Official Symbol
Clec1bprovided by MGI
Official Full Name
C-type lectin domain family 1, member bprovided by MGI
Primary source
MGI:MGI:1913287
See related
Ensembl:ENSMUSG00000030159 AllianceGenome:MGI:1913287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clec2; Clec-2; 1810061I13Rik
Summary
Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within platelet formation. Is integral component of plasma membrane. Is expressed in dorsal root ganglion; liver; lung; and spinal cord. Orthologous to human CLEC1B (C-type lectin domain family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 7.3), liver E14 (RPKM 6.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Clec1b in Genome Data Viewer
Location:
6 F3; 6 63.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129374260..129382376)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129397297..129405413)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene C-type lectin domain family 12, member a Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 9, member a Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene C-type lectin domain family 1, member a Neighboring gene STARR-seq mESC enhancer starr_17480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear. Bourne JH, et al. Thromb Haemost, 2022 Dec. PMID 35817083, Free PMC Article
  2. C-type lectin-like receptor 2 specifies a functionally distinct subpopulation within phenotypically defined hematopoietic stem cell population that contribute to emergent megakaryopoiesis. Kumode T, et al. Int J Hematol, 2022 Mar. PMID 35106701
  3. CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice. Otake S, et al. J Thromb Haemost, 2021 Jun. PMID 33774924
  4. Platelet regulates neuroinflammation and restores blood-brain barrier integrity in a mouse model of traumatic brain injury. Gao C, et al. J Neurochem, 2020 Jul. PMID 32048302
  5. Higher plasma C-type lectin-like receptor 2 concentrations for prediction of higher risk of 30-day mortality in isolated severe blunt traumatic brain injury. Guo M, et al. Clin Chim Acta, 2019 Sep. PMID 31202718

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
    Title: Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis.
  2. The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis.
    Title: The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis.
  3. CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear.
    Title: CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear.
  4. C-type lectin-like receptor 2 specifies a functionally distinct subpopulation within phenotypically defined hematopoietic stem cell population that contribute to emergent megakaryopoiesis.
    Title: C-type lectin-like receptor 2 specifies a functionally distinct subpopulation within phenotypically defined hematopoietic stem cell population that contribute to emergent megakaryopoiesis.
  5. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
    Title: CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
  6. Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.
    Title: Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.
  7. A Role of the Podoplanin-CLEC-2 Axis in Promoting Inflammatory Response After Ischemic Stroke in Mice.
    Title: A Role of the Podoplanin-CLEC-2 Axis in Promoting Inflammatory Response After Ischemic Stroke in Mice.
  8. CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice.
    Title: CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice.
  9. Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
    Title: Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2.
  10. Blocking platelet CLEC-2 signalling enhances liver recovery from acute toxic liver injuries by increasing tumour necrosis factor-alpha production which then enhances reparative hepatic neutrophil recruitment.
    Title: The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (10)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in platelet formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
C-type lectin domain family 1 member B
Names
C-type lectin-like receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204239.1 → NP_001191168.1  C-type lectin domain family 1 member B isoform 2

    See identical proteins and their annotated locations for NP_001191168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC138620
    Consensus CDS
    CCDS57452.1
    UniProtKB/Swiss-Prot
    Q9JL99
    Related
    ENSMUSP00000107712.3, ENSMUST00000112081.9
    Conserved Domains (1) summary
    cd03593
    Location:70 → 186
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_001204253.1 → NP_001191182.1  C-type lectin domain family 1 member B isoform 3

    See identical proteins and their annotated locations for NP_001191182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138620
    Consensus CDS
    CCDS57453.1
    UniProtKB/TrEMBL
    A0T1G3
    Related
    ENSMUSP00000107710.3, ENSMUST00000112079.3

  3. NM_019985.3 → NP_064369.1  C-type lectin domain family 1 member B isoform 1

    See identical proteins and their annotated locations for NP_064369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138620, BC064054
    Consensus CDS
    CCDS20586.1
    UniProtKB/Swiss-Prot
    A0T1G2, Q9JL99
    Related
    ENSMUSP00000032262.8, ENSMUST00000032262.14
    Conserved Domains (1) summary
    cd03593
    Location:102 → 218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129374260..129382376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL99.1 GenPept UniProtKB/Swiss-Prot:Q9JL99

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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