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slc12a7b solute carrier family 12 member 7b [ Danio rerio (zebrafish) ]

Gene ID: 567667, updated on 14-Nov-2024

Summary

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Official Symbol
slc12a7bprovided by ZNC
Official Full Name
solute carrier family 12 member 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-61
See related
Ensembl:ENSDARG00000062058 AllianceGenome:ZFIN:ZDB-GENE-030829-61
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb734; si:dkeyp-106g6.1
Summary
Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cranial ganglion; fin; myotome; neural tube; and sensory system. Orthologous to human SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See slc12a7b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (39778645..39885802, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (39890801..39997951, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene receptor-type tyrosine-protein phosphatase eta Neighboring gene glucose-fructose oxidoreductase domain containing 1 Neighboring gene uncharacterized LOC572443 Neighboring gene uncharacterized LOC100004848

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development. Lanni JS, et al. Dev Biol, 2019 Dec 15. PMID 31472116, Free PMC Article
  2. Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. Matos-Cruz V, et al. PLoS One, 2011. PMID 21966429, Free PMC Article
  3. Reverse genetic analysis of neurogenesis in the zebrafish retina. Pujic Z, et al. Dev Biol, 2006 May 15. PMID 16603149
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 6; solute carrier family 12 member 7
Names
bipolin
solute carrier family 12 (potassium/chloride transporter), member 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    39778645..39885802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162914.5 → XP_005162971.1  solute carrier family 12 member 7 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B9W9
    Conserved Domains (3) summary
    TIGR00930
    Location:58 → 1096
    2a30; K-Cl cotransporter
    pfam03522
    Location:724 → 1096
    SLC12; Solute carrier family 12
    cl00456
    Location:182 → 319
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_005162913.5 → XP_005162970.1  solute carrier family 12 member 7 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BA74
    Conserved Domains (3) summary
    TIGR00930
    Location:58 → 1101
    2a30; K-Cl cotransporter
    pfam03522
    Location:724 → 1101
    SLC12; Solute carrier family 12
    cl00456
    Location:182 → 319
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_005162911.5 → XP_005162968.1  solute carrier family 12 member 7 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B9W4
    Related
    ENSDARP00000083665.6, ENSDART00000089232.6
    Conserved Domains (3) summary
    TIGR00930
    Location:58 → 1133
    2a30; K-Cl cotransporter
    pfam03522
    Location:724 → 1133
    SLC12; Solute carrier family 12
    cl00456
    Location:182 → 319
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_005162910.5 → XP_005162967.1  solute carrier family 12 member 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BA14
    Conserved Domains (3) summary
    TIGR00930
    Location:58 → 1138
    2a30; K-Cl cotransporter
    pfam03522
    Location:724 → 978
    SLC12; Solute carrier family 12
    cl00456
    Location:182 → 319
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_068217266.1 → XP_068073367.1  solute carrier family 12 member 7 isoform X8

    Related
    ENSDARP00000115749.1, ENSDART00000134251.3

  6. XM_068217265.1 → XP_068073366.1  solute carrier family 12 member 7 isoform X7

  7. XM_690968.9 → XP_696060.6  solute carrier family 12 member 7 isoform X3

    UniProtKB/TrEMBL
    A0A8N7TBP4
    Conserved Domains (3) summary
    TIGR00930
    Location:39 → 1119
    2a30; K-Cl cotransporter
    pfam03522
    Location:705 → 959
    SLC12; Solute carrier family 12
    cl00456
    Location:163 → 300
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_005162915.5 → XP_005162972.1  solute carrier family 12 member 7 isoform X6

    UniProtKB/TrEMBL
    A0A8M2B9Y8
    Conserved Domains (3) summary
    TIGR00930
    Location:14 → 1094
    2a30; K-Cl cotransporter
    pfam03522
    Location:680 → 934
    SLC12; Solute carrier family 12
    cl00456
    Location:138 → 275
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version

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