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Med20 mediator complex subunit 20 [ Mus musculus (house mouse) ]

Gene ID: 56771, updated on 9-Dec-2024

Summary

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Official Symbol
Med20provided by MGI
Official Full Name
mediator complex subunit 20provided by MGI
Primary source
MGI:MGI:1929648
See related
Ensembl:ENSMUSG00000092558 AllianceGenome:MGI:1929648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trfp; 1110011O05Rik; 2410115I17Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within skeletal muscle cell differentiation. Part of mediator complex. Is expressed in several structures, including early conceptus; eye; limb mesenchyme; oocyte; and tongue. Orthologous to human MED20 (mediator complex subunit 20). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 19.5), CNS E11.5 (RPKM 17.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Med20 in Genome Data Viewer
Location:
17 C; 17 23.66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47922510..47935176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47611585..47624251)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47679075-47679320 Neighboring gene predicted gene, 41590 Neighboring gene STARR-seq mESC enhancer starr_42717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47732923-47733032 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene ubiquitin specific peptidase 49 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene fibroblast growth factor receptor substrate 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MED20 is essential for early embryogenesis and regulates NANOG expression. Cui W, et al. Reproduction, 2019 Mar. PMID 30571656, Free PMC Article
  2. Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, et al. Nat Commun, 2024 Jan 2. PMID 38168040, Free PMC Article
  3. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Tang WS, et al. Cell Rep, 2021 Jul 6. PMID 34233190
  4. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
  5. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. Sato S, et al. J Biol Chem, 2003 Apr 25. PMID 12584197

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
    Title: The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Gm20517

Readthrough gene: Gm20517, Included gene: Usp49

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 20
Names
Trf (TATA binding protein-related factor)-proximal protein homolog
ubiquitin specific protease 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364926.1 → NP_001351855.1  mediator of RNA polymerase II transcription subunit 20 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK041624, AW048999, BC060122
    UniProtKB/TrEMBL
    G3UVU6
    Related
    ENSMUST00000138638.2
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 142
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

  2. NM_001364927.1 → NP_001351856.1  mediator of RNA polymerase II transcription subunit 20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139214
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 136
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

  3. NM_020048.4 → NP_064432.1  mediator of RNA polymerase II transcription subunit 20 isoform 1

    See identical proteins and their annotated locations for NP_064432.1

    Status: VALIDATED

    Source sequence(s)
    AK041624, AK043396
    Consensus CDS
    CCDS28851.1
    UniProtKB/Swiss-Prot
    Q3UJQ7, Q3V418, Q6PAR6, Q9R0X0
    Related
    ENSMUSP00000024778.3, ENSMUST00000024778.3
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 198
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

RNA

  1. NR_157365.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK041624, AK043396, AW048999, DV065003

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47922510..47935176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0X0.1 GenPept UniProtKB/Swiss-Prot:Q9R0X0

Gene LinkOut

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