cfdp1 craniofacial development protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cfdp1provided by ZNC
Official Full Name: craniofacial development protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5736
See related: Ensembl:ENSDARG00000095086 AllianceGenome:ZFIN:ZDB-GENE-030131-5736
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gaz; fi15f05; wu:fi15f05; zgc:136405; si:dkey-6e12.6
Summary: Acts upstream of or within several processes, including bone mineralization; cerebellar granule cell differentiation; and neural retina development. Predicted to be located in kinetochore. Predicted to be part of Swr1 complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; fin bud; head; otic vesicle; and yolk syncytial layer. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: This gene, GeneID 567870, cfdp1, was represented by the incorrect symbol "rltpr", which has now been moved to GeneID 567758, carmil2. [12 Jul 2023]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (22416051..22486767)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (22426985..22497701)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cfdp1 Is Essential for Cardiac Development and Function.
Title: Cfdp1 Is Essential for Cardiac Development and Function.
The results show that CFDP1 is an essential protein required for proper development and provide the first experimental evidence showing that in vertebrates it actively participates in the morphogenesis of craniofacial territories.
Title: Functional analysis of the cfdp1 gene in zebrafish provides evidence for its crucial role in craniofacial development and osteogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: craniofacial development protein 1

Names: gazami

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100035.1 → NP_001093505.1 craniofacial development protein 1

Status: PROVISIONAL

Source sequence(s)

BX088593

UniProtKB/TrEMBL

A0A8M1NE11, A3KPL8

Related

ENSDARP00000102660.2, ENSDART00000115388.3

Conserved Domains (1) summary

pfam07572
Location:235 → 307

BCNT; Bucentaur or craniofacial development