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napepld N-acyl phosphatidylethanolamine phospholipase D [ Danio rerio (zebrafish) ]

Gene ID: 568061, updated on 2-Nov-2024

Summary

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Official Symbol
napepldprovided by ZNC
Official Full Name
N-acyl phosphatidylethanolamine phospholipase Dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3856
See related
Ensembl:ENSDARG00000009252 AllianceGenome:ZFIN:ZDB-GENE-030131-3856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc56b11; nape-pld; wu:fc56b11; zgc:158854; si:dkey-65m5.3
Summary
Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity. Predicted to be involved in N-acylethanolamine metabolic process and N-acylphosphatidylethanolamine metabolic process. Predicted to act upstream of or within phospholipid catabolic process. Predicted to be located in Golgi membrane and early endosome membrane. Predicted to be active in cytoplasm. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See napepld in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20480399..20485508, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20759419..20765007, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4a Neighboring gene leucine-rich repeats and transmembrane domains 2a Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene decapping mRNA 1B Neighboring gene integrator complex subunit 13 Neighboring gene sialic acid-binding Ig-like lectin 7 Neighboring gene Ras association domain family member 8b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Forner-Piquer I, et al. Environ Pollut, 2020 Sep. PMID 32417572
  2. The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. Krug RG 2nd, et al. PLoS One, 2018. PMID 29304078, Free PMC Article
  3. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. Martella A, et al. FASEB J, 2016 Dec. PMID 27623930
  4. Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Knuth MM, et al. J Lipid Res, 2021. PMID 34673019, Free PMC Article
  5. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Forner-Piquer I, et al. Environ Pollut, 2018 Oct. PMID 29793103

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158854

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
NP_001074082.2
XP_005164954.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080613.2 → NP_001074082.2  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

    See identical proteins and their annotated locations for NP_001074082.2

    Status: VALIDATED

    Source sequence(s)
    BX248410, CD014813, EB868982
    UniProtKB/TrEMBL
    A0A2R8RJ40, A0A8M1NCU2
    Related
    ENSDARP00000154110.1, ENSDART00000183276.1
    Conserved Domains (2) summary
    COG2220
    Location:97 → 353
    UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]
    cl23716
    Location:98 → 283
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    20480399..20485508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164897.5 → XP_005164954.2  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

    Related
    ENSDARP00000146191.1, ENSDART00000187240.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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