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aco1 aconitase 1, soluble [ Danio rerio (zebrafish) ]

Gene ID: 568448, updated on 4-Jan-2025

Summary

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Official Symbol
aco1provided by ZNC
Official Full Name
aconitase 1, solubleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031118-76
See related
Ensembl:ENSDARG00000026376 AllianceGenome:ZFIN:ZDB-GENE-031118-76
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
irp1; wu:fo75b03
Summary
Predicted to enable aconitate hydratase activity; iron-responsive element binding activity; and iron-sulfur cluster binding activity. Predicted to be involved in citrate metabolic process and tricarboxylic acid cycle. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in blood and presumptive blood. Orthologous to human ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See aco1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71458645..71489738, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71221831..71248624, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat LGI family, member 2a Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase Neighboring gene leucine-rich melanocyte differentiation-associated protein Neighboring gene protein phosphatase 1, regulatory subunit 15A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Haem oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. Luo K, et al. FEBS J, 2022 Feb. PMID 34544203
  2. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Wingert RA, et al. Nature, 2005 Aug 18. PMID 16110529
  3. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
  4. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
  5. Thifluzamide induces the toxic effects on zebrafish (Danio rerio) via inhibition of succinate dehydrogenase (SDH). Yang Y, et al. Environ Pollut, 2020 Oct. PMID 32806454

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in citrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic aconitate hydratase
Names
iron regulatory protein 1
NP_001030155.1
XP_005172430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034983.1 → NP_001030155.1  cytoplasmic aconitate hydratase

    See identical proteins and their annotated locations for NP_001030155.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ083332
    UniProtKB/TrEMBL
    Q3YMK9
    Related
    ENSDARP00000045252.6, ENSDART00000045253.8
    Conserved Domains (3) summary
    cd01586
    Location:82 → 566
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:670 → 837
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:3 → 886
    PTZ00092; aconitate hydratase-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71458645..71489738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172373.5 → XP_005172430.1  cytoplasmic aconitate hydratase isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJL9, F1QM42
    Conserved Domains (3) summary
    cd01586
    Location:82 → 566
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:670 → 837
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:3 → 886
    PTZ00092; aconitate hydratase-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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