sdc4 syndecan 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sdc4provided by ZNC
Official Full Name: syndecan 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-061111-1
See related: Ensembl:ENSDARG00000059906 AllianceGenome:ZFIN:ZDB-GENE-061111-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sdc4l; wu:fc47g09
Summary: Enables phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; neuronal stem cell division; and stress fiber assembly. Located in focal adhesion. Is expressed in brain; neural crest; posterior lateral line primordium; and prechordal plate. Orthologous to human SDC4 (syndecan 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (52663106..52675650, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (52666001..52677172, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration.
Title: Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration.
Collectively, these data indicate that Syn4 suppresses the cellular proliferation during neurogenesis and is crucial for the formation of caudal primary axons during zebrafish embryogenesis.
Title: Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis.
We show here that sdc2,sdc3 and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
Title: Distinct expression patterns of syndecans in the embryonic zebrafish brain.
cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan gene duplication events at the invertebrate/early chordate boundary
Title: Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: syndecan-4

Names: ryudocan core protein; syn4; syndecan 4 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.