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fat3a FAT atypical cadherin 3a [ Danio rerio (zebrafish) ]

Gene ID: 569256, updated on 17-Sep-2024

Summary

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Official Symbol
fat3aprovided by ZNC
Official Full Name
FAT atypical cadherin 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-1254
See related
Ensembl:ENSDARG00000033840 AllianceGenome:ZFIN:ZDB-GENE-060929-1254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fat3; zgc:153498
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within cartilage morphogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in Meckel's cartilage; palatoquadrate cartilage; and pectoral fin. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fat3a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (40665394..40993759)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (40708007..41032567)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103908864 Neighboring gene uncharacterized LOC137487789 Neighboring gene melatonin receptor type 1Ba Neighboring gene solute carrier family 36 member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. Le Pabic P, et al. PLoS Genet, 2014 Oct. PMID 25340762, Free PMC Article
  2. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Wang X, et al. Biol Open, 2013. PMID 24244857, Free PMC Article
  3. Molecular evolution of melatonin receptor genes (mtnr) in vertebrates and its shedding light on mtnr1c. Li Y, et al. Gene, 2021 Feb 15. PMID 33164759
  4. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
  5. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153498

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin Fat 3a
Names
FAT atypical cadherin 3
FAT tumor suppressor homolog 3 like
zmp:0000000581

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077577.3 → NP_001071045.2  protocadherin Fat 3a precursor

    Status: VALIDATED

    Source sequence(s)
    AL929284, CR388051, CR524482
    UniProtKB/TrEMBL
    A0A8M1NBU7, F1QA09
    Related
    ENSDARP00000042081.7, ENSDART00000042082.8

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    40665394..40993759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017350986.3 → XP_017206475.1  protocadherin Fat 3a isoform X1

    UniProtKB/TrEMBL
    A0A2R8QAL3, A0A8M6YUT6
    Related
    ENSDARP00000150399.1, ENSDART00000184559.1

  2. XM_021481446.2 → XP_021337121.1  protocadherin Fat 3a isoform X3

    UniProtKB/TrEMBL
    A0A8M9QLG7
    Conserved Domains (4) summary
    cd11304
    Location:3289 → 3385
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:1435 → 1494
    CA; Cadherin repeats
    cd00054
    Location:4147 → 4182
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3914 → 4043
    Laminin_G_2; Laminin G domain

  3. XM_021481445.2 → XP_021337120.1  protocadherin Fat 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M9QPX2, X1WCY4
    Related
    ENSDARP00000128081.1, ENSDART00000154187.3
    Conserved Domains (3) summary
    cd11304
    Location:3266 → 3362
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:4124 → 4159
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3891 → 4020
    Laminin_G_2; Laminin G domain

  4. XM_017350989.3 → XP_017206478.1  protocadherin Fat 3a isoform X4

    UniProtKB/TrEMBL
    A0A8M6Z1C0
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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