U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SHD Src homology 2 domain containing transforming protein D [ Homo sapiens (human) ]

Gene ID: 56961, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SHDprovided by HGNC
Official Full Name
Src homology 2 domain containing transforming protein Dprovided by HGNC
Primary source
HGNC:HGNC:30633
See related
Ensembl:ENSG00000105251 MIM:610481; AllianceGenome:HGNC:30633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 6.5), heart (RPKM 2.0) and 5 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SHD in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4279069..4290722)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4262345..4273993)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4279066..4290719)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4230793-4231294 Neighboring gene Epstein-Barr virus induced 3 Neighboring gene MPRA-validated peak3276 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4246137-4246908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13766 Neighboring gene YJU2 splicing factor homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9883 Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4301847-4302392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9884 Neighboring gene fibronectin type III and SPRY domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oda T, et al. Oncogene, 1997 Sep. PMID 9315092
  2. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Leung KK, et al. Mol Cell Proteomics, 2014 Jul. PMID 24728074, Free PMC Article
  3. Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors. Hause RJ Jr, et al. PLoS One, 2012. PMID 22973453, Free PMC Article
  4. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
SH2 domain-containing adapter protein D
Names
src homology 2 domain-containing transforming protein D

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372011.1 → NP_001358940.1  SH2 domain-containing adapter protein D

    Status: VALIDATED

    Source sequence(s)
    AC008616, BC007206
    Consensus CDS
    CCDS12125.1
    UniProtKB/Swiss-Prot
    Q96IW2, Q96NC2
    UniProtKB/TrEMBL
    M0QYZ4
    Conserved Domains (1) summary
    cd10390
    Location:238 → 335
    SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

  2. NM_020209.4 → NP_064594.3  SH2 domain-containing adapter protein D

    See identical proteins and their annotated locations for NP_064594.3

    Status: VALIDATED

    Source sequence(s)
    AC008616, BC007206
    Consensus CDS
    CCDS12125.1
    UniProtKB/Swiss-Prot
    Q96IW2, Q96NC2
    UniProtKB/TrEMBL
    M0QYZ4
    Related
    ENSP00000446058.1, ENST00000543264.7
    Conserved Domains (1) summary
    cd10390
    Location:238 → 335
    SH2_SHD; Src homology 2 domain found in SH2 domain-containing adapter proteins D (SHD)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4279069..4290722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4262345..4273993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96IW2.1 GenPept UniProtKB/Swiss-Prot:Q96IW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools