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arhgap33 Rho GTPase activating protein 33 [ Danio rerio (zebrafish) ]

Gene ID: 569720, updated on 17-Sep-2024

Summary

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Official Symbol
arhgap33provided by ZNC
Official Full Name
Rho GTPase activating protein 33provided by ZNC
Primary source
ZFIN:ZDB-GENE-121105-12
See related
AllianceGenome:ZFIN:ZDB-GENE-121105-12
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc76f02
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to act upstream of or within protein transport and signal transduction. Orthologous to human ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See arhgap33 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (44783675..44878323, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (44816959..44911809, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000951 Neighboring gene uroplakin 1a Neighboring gene RNA binding motif protein 42 Neighboring gene cd22 molecule Neighboring gene neural cell adhesion molecule 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 33
Names
SNX26

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    44783675..44878323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158402.5 → XP_005158459.3  rho GTPase-activating protein 33 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5A9
    Conserved Domains (3) summary
    cd07299
    Location:93 → 207
    PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
    cd11835
    Location:229 → 282
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:356 → 550
    RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

  2. XM_068214240.1 → XP_068070341.1  rho GTPase-activating protein 33 isoform X1

  3. XM_068214244.1 → XP_068070345.1  rho GTPase-activating protein 33 isoform X6

  4. XM_068214245.1 → XP_068070346.1  rho GTPase-activating protein 33 isoform X6

  5. XM_005158403.5 → XP_005158460.1  rho GTPase-activating protein 33 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B593
    Conserved Domains (3) summary
    cd07299
    Location:81 → 195
    PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
    cd11835
    Location:217 → 270
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:344 → 538
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

  6. XM_068214241.1 → XP_068070342.1  rho GTPase-activating protein 33 isoform X3

  7. XM_068214243.1 → XP_068070344.1  rho GTPase-activating protein 33 isoform X6

  8. XM_068214242.1 → XP_068070343.1  rho GTPase-activating protein 33 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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