plvapb plasmalemma vesicle associated protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plvapbprovided by ZNC
Official Full Name: plasmalemma vesicle associated protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060616-96
See related: Ensembl:ENSDARG00000045003 AllianceGenome:ZFIN:ZDB-GENE-060616-96
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vsg1; plvap; fb11a07; wu:fb11a07; zgc:113451; zgc:136228
Summary: Acts upstream of or within Notch signaling pathway and regulation of vascular permeability. Predicted to be located in membrane. Is expressed in vasculature. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (6043742..6048428, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (6046487..6051173, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular extravasation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vascular permeability	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasmalemma vesicle associated protein b

Names: vessel-specific 1; zvsg1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030244.3 → NP_001025415.3 plasmalemma vesicle associated protein b

Status: VALIDATED

Source sequence(s)

BC091873, BC117570

UniProtKB/TrEMBL

A0A8M1N7E0, F1Q8W5, Q1ED33, Q58EJ6

Related

ENSDARP00000066163.4, ENSDART00000066164.5

Conserved Domains (1) summary

pfam06637
Location:27 → 375

PV-1; PV-1 protein (PLVAP)