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igfals insulin-like growth factor binding protein, acid labile subunit [ Danio rerio (zebrafish) ]

Gene ID: 570758, updated on 2-Nov-2024

Summary

Official Symbol
igfalsprovided by ZNC
Official Full Name
insulin-like growth factor binding protein, acid labile subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061009-25
See related
Ensembl:ENSDARG00000037836 AllianceGenome:ZFIN:ZDB-GENE-061009-25
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-66h3.1
Summary
Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in brain; digestive system; heart; muscle; and pleuroperitoneal region. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See igfals in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (45845786..45848295, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (47893452..47895928, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 8 Neighboring gene unk like zinc finger Neighboring gene shisa family member 9b Neighboring gene uncharacterized LOC137490752

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of insulin-like growth factor ternary complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein complex acid labile subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    45845786..45848295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003198155.6XP_003198203.1  insulin-like growth factor-binding protein complex acid labile subunit

    UniProtKB/TrEMBL
    A0A8M1RSH4, E9QJJ1, F1R1F2
    Related
    ENSDARP00000122885.1, ENSDART00000147198.2
    Conserved Domains (4) summary
    cd00116
    Location:219456
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:108131
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:4881
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:227286
    LRR_8; Leucine rich repeat