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fhod3b formin homology 2 domain containing 3b [ Danio rerio (zebrafish) ]

Gene ID: 570795, updated on 2-Nov-2024

Summary

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Official Symbol
fhod3bprovided by ZNC
Official Full Name
formin homology 2 domain containing 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081028-61
See related
AllianceGenome:ZFIN:ZDB-GENE-081028-61
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:103746; si:ch211-209d1.1
Summary
Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See fhod3b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (18605242..18960568, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (18802177..19155094, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487889 Neighboring gene retinoid x receptor, beta b Neighboring gene si:ch211-254p10.2 Neighboring gene solute carrier family 6 member 19b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy. Lesurf R, et al. NPJ Genom Med, 2022 Mar 14. PMID 35288587, Free PMC Article
  2. Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Lee HJ, et al. Genome Biol, 2020 Feb 27. PMID 32106888, Free PMC Article
  3. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC103746

General protein information

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Preferred Names
FH1/FH2 domain-containing protein 3
Names
formin homology 2 domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    18605242..18960568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466894.2 → XP_021322569.1  FH1/FH2 domain-containing protein 3 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PDK4
    Conserved Domains (1) summary
    pfam02181
    Location:969 → 1338
    FH2; Formin Homology 2 Domain

  2. XM_021466893.2 → XP_021322568.1  FH1/FH2 domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A8M9P8A0
    Conserved Domains (1) summary
    pfam02181
    Location:985 → 1354
    FH2; Formin Homology 2 Domain

  3. XM_068214113.1 → XP_068070214.1  FH1/FH2 domain-containing protein 3 isoform X4

  4. XM_021466892.2 → XP_021322567.1  FH1/FH2 domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9NZN4
    Conserved Domains (1) summary
    pfam02181
    Location:1010 → 1379
    FH2; Formin Homology 2 Domain

  5. XM_068214112.1 → XP_068070213.1  FH1/FH2 domain-containing protein 3 isoform X2

  6. XM_021466891.2 → XP_021322566.1  FH1/FH2 domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PK03
    Conserved Domains (1) summary
    pfam02181
    Location:1145 → 1514
    FH2; Formin Homology 2 Domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394959.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    224396..235036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472977.2 → XP_021328652.1  FH1/FH2 domain-containing protein 3 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PC43

  2. XM_021472978.2 → XP_021328653.1  FH1/FH2 domain-containing protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A8M9PNP0
Nucleotide Protein Strain
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