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ankha ANKH inorganic pyrophosphate transport regulator a [ Danio rerio (zebrafish) ]

Gene ID: 571148, updated on 2-Nov-2024

Summary

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Official Symbol
ankhaprovided by ZNC
Official Full Name
ANKH inorganic pyrophosphate transport regulator aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-33
See related
Ensembl:ENSDARG00000071724 AllianceGenome:ZFIN:ZDB-GENE-050913-33
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj64g09; zgc:110290
Summary
Predicted to enable inorganic diphosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Predicted to act upstream of or within phosphate ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ankha in Genome Data Viewer
Location:
chromosome: 24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (10349147..10394277, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (10208761..10253891, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene POU class 6 homeobox 2 Neighboring gene fibrous sheath CABYR-binding protein Neighboring gene OTU deubiquitinase with linear linkage specificity a Neighboring gene si:ch211-69l10.4 Neighboring gene MYC proto-oncogene, bHLH transcription factor a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and Validation of a Complete Knockout Model of abcc6a in Zebrafish. Van Gils M, et al. J Invest Dermatol, 2018 Nov. PMID 30030150
  2. Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Laue K, et al. Am J Hum Genet, 2011 Nov 11. PMID 22019272, Free PMC Article
  3. Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development. Jeradi S, et al. Development, 2016 Apr 1. PMID 26903503, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC110290

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables inorganic diphosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ANKH inorganic pyrophosphate transport regulator a
Names
ankylosis, progressive homolog a
progressive ankylosis-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030259.2 → NP_001025430.2  ANKH inorganic pyrophosphate transport regulator a

    Status: VALIDATED

    Source sequence(s)
    CR391965, CT573344
    UniProtKB/TrEMBL
    A0A8M1N7I5, F1Q528
    Related
    ENSDARP00000105177.1, ENSDART00000127568.3
    Conserved Domains (1) summary
    pfam07260
    Location:1 → 344
    ANKH; Progressive ankylosis protein (ANKH)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    10349147..10394277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470216.2 → XP_021325891.1  ANKH inorganic pyrophosphate transport regulator a isoform X2

    UniProtKB/TrEMBL
    A0A8M9PU68
    Conserved Domains (1) summary
    pfam07260
    Location:1 → 232
    ANKH; Progressive ankylosis protein (ANKH)

  2. XM_068217103.1 → XP_068073204.1  ANKH inorganic pyrophosphate transport regulator a isoform X1

    Related
    ENSDARP00000114225.1, ENSDART00000144688.3
Nucleotide Protein
Heading Accession and Version

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