pomgnt1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pomgnt1provided by ZNC
Official Full Name: protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-991
See related: Ensembl:ENSDARG00000052025 AllianceGenome:ZFIN:ZDB-GENE-070112-991
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zPOMGnT1; im:7151461; zgc:158130
Summary: Predicted to enable beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity. Acts upstream of or within eye morphogenesis. Is active in secretory vesicle. Is expressed in several structures, including axis; fin bud; myotome; nervous system; and shield. Human ortholog(s) of this gene implicated in lissencephaly; muscular dystrophy (multiple); and retinitis pigmentosa. Orthologous to human POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (33076839..33095766)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (33092149..33111076)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in O-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory vesicle	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Names: Protein O-Mannose beta-1,2-N-acetylglucosaminyltransferase 1; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase

NP_001036152.3

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042687.3 → NP_001036152.3 protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

Status: VALIDATED

Source sequence(s)

BC097123, CR848680, DQ826747, EB893193

UniProtKB/TrEMBL

A0A8M1N8Z7, F1QNB2, Q0PIP4

Related

ENSDARP00000068245.4, ENSDART00000073755.6

Conserved Domains (2) summary

cd02514
Location:296 → 623

GT13_GLCNAC-TI; GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides

cd13937
Location:94 → 241

PANDER_GnT-1_2_like; PANDER-like domain of N-acetylglucosaminyltransferases