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slmapa sarcolemma associated protein a [ Danio rerio (zebrafish) ]

Gene ID: 572011, updated on 17-Aug-2024

Summary

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Official Symbol
slmapaprovided by ZNC
Official Full Name
sarcolemma associated protein aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-184
See related
Ensembl:ENSDARG00000054458 AllianceGenome:ZFIN:ZDB-GENE-061013-184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa03e05; fb39b03; wu:fa03e05; wu:fb39b03; zgc:153887
Summary
Predicted to be involved in protein localization to plasma membrane; regulation of membrane depolarization during cardiac muscle cell action potential; and regulation of voltage-gated sodium channel activity. Predicted to act upstream of or within muscle contraction. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (42305549..42418379, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42036675..42148441, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911880 Neighboring gene filamin B, like Neighboring gene DENN/MADD domain containing 6Aa Neighboring gene ADP-ribosylation factor 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane depolarization during cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sarcolemma associated protein a; sarcolemmal membrane-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077254.1 → NP_001070722.1  sarcolemma associated protein a

    See identical proteins and their annotated locations for NP_001070722.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124763
    UniProtKB/TrEMBL
    A0A8M1NB23, Q08BE3
    Related
    ENSDARP00000138370.1, ENSDART00000160704.2
    Conserved Domains (5) summary
    COG1716
    Location:46 → 109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:14 → 108
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:163 → 793
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17023
    Location:287 → 475
    DUF5098; Domain of unknown function (DUF5098)
    cl19219
    Location:297 → 367
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    42305549..42418379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168063.4 → XP_005168120.1  sarcolemmal membrane-associated protein isoform X4

    UniProtKB/TrEMBL
    A0A8M2BFI3
    Conserved Domains (4) summary
    COG1716
    Location:46 → 109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:14 → 108
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:163 → 776
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl19219
    Location:297 → 367
    DUF342; Protein of unknown function (DUF342)

  2. XM_005168062.4 → XP_005168119.1  sarcolemmal membrane-associated protein isoform X3

    UniProtKB/TrEMBL
    A0A8M2BFH7
    Conserved Domains (5) summary
    COG1716
    Location:46 → 109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:14 → 108
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:163 → 793
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17023
    Location:287 → 475
    DUF5098; Domain of unknown function (DUF5098)
    cl19219
    Location:297 → 367
    DUF342; Protein of unknown function (DUF342)

  3. XM_005168060.4 → XP_005168117.1  sarcolemmal membrane-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A2R8QQ99, A0A8M2BG26
    Related
    ENSDARP00000155262.1, ENSDART00000191086.1
    Conserved Domains (5) summary
    COG1716
    Location:46 → 109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:14 → 108
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:163 → 814
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17023
    Location:287 → 496
    DUF5098; Domain of unknown function (DUF5098)
    cl19219
    Location:297 → 367
    DUF342; Protein of unknown function (DUF342)

  4. XM_005168061.4 → XP_005168118.1  sarcolemmal membrane-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFG9
    Conserved Domains (5) summary
    COG1716
    Location:46 → 109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:14 → 108
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    TIGR02168
    Location:163 → 814
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17023
    Location:287 → 496
    DUF5098; Domain of unknown function (DUF5098)
    cl19219
    Location:297 → 367
    DUF342; Protein of unknown function (DUF342)

  5. XM_005168064.4 → XP_005168121.1  sarcolemmal membrane-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A8M2BFI9
    Conserved Domains (2) summary
    TIGR02168
    Location:4 → 655
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl19219
    Location:138 → 208
    DUF342; Protein of unknown function (DUF342)
Nucleotide Protein Strain
Heading Accession and Version

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