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Bcam basal cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 57278, updated on 9-Dec-2024

Summary

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Official Symbol
Bcamprovided by MGI
Official Full Name
basal cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:1929940
See related
Ensembl:ENSMUSG00000002980 AllianceGenome:MGI:1929940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lu; Gplu; B-CAM; 1200005K12Rik
Summary
Enables laminin receptor activity. Acts upstream of or within cell adhesion. Located in cell surface and plasma membrane. Is expressed in several structures, including genitourinary system; nervous system; skin; small intestine; and spleen. Orthologous to human BCAM (basal cell adhesion molecule (Lutheran blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in lung adult (RPKM 346.1), ovary adult (RPKM 101.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Bcam in Genome Data Viewer
Location:
7 A3; 7 9.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19490063..19504457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19756138..19770532, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene Casitas B-lineage lymphoma c Neighboring gene STARR-positive B cell enhancer ABC_E2816 Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse. Rahuel C, et al. Am J Physiol Renal Physiol, 2008 Feb. PMID 18032551
  2. Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice. Huang J, et al. Kidney Int, 2014 May. PMID 24429403, Free PMC Article
  3. Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way. Soffer A, et al. PLoS Biol, 2022 Aug. PMID 35969606, Free PMC Article
  4. Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. Miura Y, et al. Elife, 2018 Jul 30. PMID 30059007, Free PMC Article
  5. Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene. Rahuel C, et al. Immunogenetics, 1999 Dec. PMID 10630290

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lutheran (Lu)/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models.
    Title: Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration.
  2. Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury in crescentic glomerulonephritis.
    Title: Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice.
  3. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
    Title: The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein.
  4. Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.
    Title: Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables laminin binding IEA
Inferred from Electronic Annotation
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables laminin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables laminin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
basal cell adhesion molecule
Names
Auberger b antigen
B-CAM cell surface glycoprotein
Lutheran blood group
lutheran antigen
lutheran glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020486.2 → NP_065232.1  basal cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_065232.1

    Status: VALIDATED

    Source sequence(s)
    AF109160, AF221507, AF346663, BB190832
    Consensus CDS
    CCDS39803.1
    UniProtKB/Swiss-Prot
    Q9ESS5, Q9JKB2, Q9R069
    UniProtKB/TrEMBL
    Q99K86
    Related
    ENSMUSP00000003061.8, ENSMUST00000003061.14
    Conserved Domains (5) summary
    smart00408
    Location:276 → 334
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:32 → 136
    IG_like; Immunoglobulin like
    pfam08205
    Location:144 → 241
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:371 → 438
    Ig_2; Immunoglobulin domain
    cl11960
    Location:460 → 523
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19490063..19504457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R069.1 GenPept UniProtKB/Swiss-Prot:Q9R069

Gene LinkOut

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