tpmt.2 thiopurine S-methyltransferase, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tpmt.2provided by ZNC
Official Full Name: thiopurine S-methyltransferase, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-177
See related: Ensembl:ENSDARG00000028012 AllianceGenome:ZFIN:ZDB-GENE-041010-177
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101684; si:ch73-345a19.3
Summary: Predicted to enable thiopurine S-methyltransferase activity. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (47299166..47309583)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (47707359..47717987)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables thiopurine S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiopurine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thiopurine S-methyltransferase, tandem duplicate 2

NP_001028758.1

EC 2.1.1.67

XP_005159845.1

EC 2.1.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033586.1 → NP_001028758.1 thiopurine S-methyltransferase, tandem duplicate 2

See identical proteins and their annotated locations for NP_001028758.1

Status: PROVISIONAL

Source sequence(s)

BC083246

UniProtKB/Swiss-Prot

Q504A5

UniProtKB/TrEMBL

Q5XJQ2

Conserved Domains (1) summary

pfam05724
Location:9 → 244

TPMT; Thiopurine S-methyltransferase (TPMT)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

47299166..47309583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159788.4 → XP_005159845.1 thiopurine S-methyltransferase, tandem duplicate 2 isoform X1

UniProtKB/Swiss-Prot

Q504A5

UniProtKB/TrEMBL

A0A8M2B6W4, F8W621

Related

ENSDARP00000138689.2, ENSDART00000158262.2

Conserved Domains (1) summary

pfam05724
Location:9 → 230

TPMT; Thiopurine S-methyltransferase (TPMT)