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acadvl acyl-CoA dehydrogenase very long chain [ Danio rerio (zebrafish) ]

Gene ID: 573723, updated on 9-Dec-2024

Summary

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Official Symbol
acadvlprovided by ZNC
Official Full Name
acyl-CoA dehydrogenase very long chainprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-899
See related
Ensembl:ENSDARG00000016687 AllianceGenome:ZFIN:ZDB-GENE-030131-899
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb52d04; zgc:64067; wu:fb52d04; wu:fc75e01
Summary
Predicted to enable fatty-acyl-CoA binding activity and very-long-chain fatty acyl-CoA dehydrogenase activity. Acts upstream of or within head development. Predicted to be located in mitochondrial inner membrane. Is expressed in female organism; pectoral fin musculature; and pronephric duct. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See acadvl in Genome Data Viewer
Location:
chromosome: 7
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (20298396..20333123)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (20046469..20080639)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch73-335l21.2 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene zgc:194312 Neighboring gene plac8 onzin related protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Carvalho CM, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439725, Free PMC Article
  2. Enantioselective bioaccumulation following exposure of adult zebrafish (Danio rerio) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Wang Y, et al. Environ Pollut, 2017 Oct. PMID 28601015
  3. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Liu Y, et al. Aquat Toxicol, 2008 Sep 29. PMID 18760846
  4. DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Ding Q, et al. Front Nutr, 2021. PMID 35145984, Free PMC Article
  5. Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. Tian J, et al. Cells, 2022 Jun 9. PMID 35740999, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64067, MGC174519

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within head development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
acyl-Coenzyme A dehydrogenase, very long chain
vlcad
NP_997776.1
XP_068078474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212611.1 → NP_997776.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_997776.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054606
    UniProtKB/TrEMBL
    Q7T2C2
    Related
    ENSDARP00000007240.7, ENSDART00000023089.9
    Conserved Domains (2) summary
    cd01161
    Location:77 → 486
    VLCAD; Very long chain acyl-CoA dehydrogenase
    COG1960
    Location:107 → 478
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    20298396..20333123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222373.1 → XP_068078474.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

    Related
    ENSDARP00000112163.1, ENSDART00000131019.3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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