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STRIP2 striatin interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 57464, updated on 14-Nov-2024

Summary

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Official Symbol
STRIP2provided by HGNC
Official Full Name
striatin interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:22209
See related
Ensembl:ENSG00000128578 MIM:617919; AllianceGenome:HGNC:22209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM40B; FAR11B
Summary
Involved in cell migration; cytoskeleton organization; and regulation of cell shape. Located in cytosol. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 7.5), brain (RPKM 4.0) and 9 other tissues See more
Orthologs
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Genomic context

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See STRIP2 in Genome Data Viewer
Location:
7q32.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (129434432..129488399)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130747403..130801465)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129074273..129128240)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase like 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:129059227-129059428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18629 Neighboring gene RNA, U7 small nuclear 16 pseudogene Neighboring gene cell division cycle 26 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr7:129109680-129110219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18631 Neighboring gene RNA, U1 small nuclear 72, pseudogene Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129166309-129166810 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129173685-129174202 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:129174203-129174720 Neighboring gene small lysine rich protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:129201761-129202261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26632 Neighboring gene nuclear respiratory factor 1 Neighboring gene Sharpr-MPRA regulatory region 6855 Neighboring gene RNA, 5S ribosomal pseudogene 244

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration. Qiu LM, et al. FEBS Open Bio, 2020 Mar. PMID 31901223, Free PMC Article
  2. STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway. Pan J, et al. Genomics, 2024 Sep. PMID 39191354
  3. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent. Zhang X, et al. J Exp Clin Cancer Res, 2023 Jan 13. PMID 36639675, Free PMC Article
  4. The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs. Suryavanshi N, et al. BMC Cell Biol, 2018 Dec 3. PMID 30509168, Free PMC Article
  5. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Eden M, et al. Nat Commun, 2016 Apr 28. PMID 27122098, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway.
    Title: STRIP2 is regulated by the transcription factor Sp1 and promotes lung adenocarcinoma progression via activating the PI3K/AKT/mTOR/MYC signaling pathway.
  2. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.
    Title: STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.
  3. STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration.
    Title: STRIP2, a member of the striatin-interacting phosphatase and kinase complex, is implicated in lung adenocarcinoma cell growth and migration.
  4. These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex.
    Title: The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.
  5. Data indicate that a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel CaV1.2.
    Title: Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
  6. this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage.
    Title: STRIPAK components determine mode of cancer cell migration and metastasis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
striatin-interacting protein 2
Names
FAR11 factor arrest 11 homolog B
family with sequence similarity 40, member B
homolog of yeast FAR11 protein 2
protein FAM40B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134336.2 → NP_001127808.1  striatin-interacting protein 2 isoform b

    See identical proteins and their annotated locations for NP_001127808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC009244, BC019064, DA409007
    Consensus CDS
    CCDS47709.1
    UniProtKB/TrEMBL
    A8K2A0
    Related
    ENSP00000392393.2, ENST00000435494.2
    Conserved Domains (2) summary
    pfam07923
    Location:49 → 326
    N1221; N1221-like protein
    pfam11882
    Location:456 → 751
    DUF3402; Domain of unknown function (DUF3402)

  2. NM_020704.3 → NP_065755.1  striatin-interacting protein 2 isoform a

    See identical proteins and their annotated locations for NP_065755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB032996, AC009244, DA409007
    Consensus CDS
    CCDS34752.1
    UniProtKB/Swiss-Prot
    Q8WUZ4, Q9ULQ0
    UniProtKB/TrEMBL
    A8K2A0
    Related
    ENSP00000249344.2, ENST00000249344.7
    Conserved Domains (2) summary
    pfam07923
    Location:49 → 338
    N1221; N1221-like protein
    pfam11882
    Location:456 → 779
    DUF3402; Domain of unknown function (DUF3402)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    129434432..129488399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716069.4 → XP_006716132.1  striatin-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    A8K2A0
    Conserved Domains (2) summary
    pfam07923
    Location:49 → 338
    N1221; N1221-like protein
    pfam11882
    Location:456 → 684
    DUF3402; Domain of unknown function (DUF3402)

  2. XM_017012470.2 → XP_016867959.1  striatin-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    pfam07923
    Location:49 → 338
    N1221; N1221-like protein
    pfam11882
    Location:456 → 625
    DUF3402; Domain of unknown function (DUF3402)

  3. XM_047420656.1 → XP_047276612.1  striatin-interacting protein 2 isoform X5

  4. XM_011516435.2 → XP_011514737.1  striatin-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    pfam07923
    Location:49 → 338
    N1221; N1221-like protein
    pfam11882
    Location:456 → 485
    DUF3402; Domain of unknown function (DUF3402)

  5. XM_011516432.2 → XP_011514734.1  striatin-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K2A0
    Conserved Domains (2) summary
    pfam07923
    Location:1 → 177
    N1221; N1221-like protein
    pfam11882
    Location:295 → 618
    DUF3402; Domain of unknown function (DUF3402)

  6. XM_017012471.1 → XP_016867960.1  striatin-interacting protein 2 isoform X4

  7. XM_047420657.1 → XP_047276613.1  striatin-interacting protein 2 isoform X7

RNA

  1. XR_927493.2 RNA Sequence

  2. XR_001744840.2 RNA Sequence

  3. XR_001744841.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    130747403..130801465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358707.1 → XP_054214682.1  striatin-interacting protein 2 isoform X1

  2. XM_054358708.1 → XP_054214683.1  striatin-interacting protein 2 isoform X2

  3. XM_054358711.1 → XP_054214686.1  striatin-interacting protein 2 isoform X5

  4. XM_054358712.1 → XP_054214687.1  striatin-interacting protein 2 isoform X6

  5. XM_054358709.1 → XP_054214684.1  striatin-interacting protein 2 isoform X3

  6. XM_054358710.1 → XP_054214685.1  striatin-interacting protein 2 isoform X4

  7. XM_054358713.1 → XP_054214688.1  striatin-interacting protein 2 isoform X7

RNA

  1. XR_008487709.1 RNA Sequence

  2. XR_008487707.1 RNA Sequence

  3. XR_008487708.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULQ0.2 GenPept UniProtKB/Swiss-Prot:Q9ULQ0

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