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Rpl35a ribosomal protein L35A [ Mus musculus (house mouse) ]

Gene ID: 57808, updated on 9-Dec-2024

Summary

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Official Symbol
Rpl35aprovided by MGI
Official Full Name
ribosomal protein L35Aprovided by MGI
Primary source
MGI:MGI:1928894
See related
Ensembl:ENSMUSG00000060636 AllianceGenome:MGI:1928894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpl35; 2810431L15Rik
Summary
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; rRNA processing; and ribosomal large subunit biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in central nervous system; cranium; gut; inner ear; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver E14 (RPKM 309.5), bladder adult (RPKM 301.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl35a in Genome Data Viewer
Location:
16 B3; 16 23.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32876823..32880559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33056453..33060189)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene nuclear encoded rRNA 5S 33 Neighboring gene STARR-seq mESC enhancer starr_40679 Neighboring gene STARR-positive B cell enhancer ABC_E8628 Neighboring gene IQ motif containing G Neighboring gene STARR-positive B cell enhancer ABC_E2460 Neighboring gene leishmanolysin-like (metallopeptidase M8 family) Neighboring gene microRNA 1947 Neighboring gene predicted gene, 38540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and expression of a cDNA encoding the mouse L35a ribosomal protein during differentiation of murine erythroleukemia (MEL) cells. Pappas IS, et al. Cell Biol Int, 2001. PMID 11448102
  2. cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Hemberger M, et al. Dev Biol, 2000 Jun 1. PMID 10885754
  3. A male germ-cell-specific ribosome controls male fertility. Li H, et al. Nature, 2022 Dec. PMID 36517592
  4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  5. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Kondrashov N, et al. Cell, 2011 Apr 29. PMID 21529712, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL33
Names
60S ribosomal protein L35a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130484.1 → NP_001123956.1  large ribosomal subunit protein eL33

    See identical proteins and their annotated locations for NP_001123956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    BB611247, CJ043213
    Consensus CDS
    CCDS28126.1
    UniProtKB/Swiss-Prot
    O55142
    UniProtKB/TrEMBL
    Q6ZWX1, Q8BQV7, Q9DC85
    Related
    ENSMUSP00000110731.2, ENSMUST00000115079.8
    Conserved Domains (1) summary
    pfam01247
    Location:5 → 103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

  2. NM_001130485.1 → NP_001123957.1  large ribosomal subunit protein eL33

    See identical proteins and their annotated locations for NP_001123957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK010692, BB611247, BU530423
    Consensus CDS
    CCDS28126.1
    UniProtKB/Swiss-Prot
    O55142
    UniProtKB/TrEMBL
    Q6ZWX1, Q8BQV7, Q9DC85
    Related
    ENSMUSP00000077857.6, ENSMUST00000078804.12
    Conserved Domains (1) summary
    pfam01247
    Location:5 → 103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

  3. NM_021338.3 → NP_067313.2  large ribosomal subunit protein eL33

    See identical proteins and their annotated locations for NP_067313.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK028214, AV486753, BB611247
    Consensus CDS
    CCDS28126.1
    UniProtKB/Swiss-Prot
    O55142
    UniProtKB/TrEMBL
    Q6ZWX1, Q8BQV7, Q9DC85
    Related
    ENSMUSP00000110730.2, ENSMUST00000115078.8
    Conserved Domains (1) summary
    pfam01247
    Location:5 → 103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32876823..32880559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55142.2 GenPept UniProtKB/Swiss-Prot:O55142

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